Evidence mapPaperPMID 41918706Full record

ArticleInternational journal of public health2026

Moderate Wine Consumption, Defined by the Mediterranean Diet, Is Associated With Delayed Biological Aging in Men From the Moli-sani Study.

Simona Esposito, Augusto Di Castelnuovo, Simona Costanzo, Alessandro Gialluisi, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Sara Magnacca, Mariarosaria Persichillo, Francesc Casanovas-Garriga and 5 more

Erratum issuedAbstract read
In one paragraph

Article in International journal of public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Simona EspositoResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Augusto Di CastelnuovoResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Simona CostanzoResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Alessandro GialluisiResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Antonietta PepeDepartment of Medicine and Surgery, LUM University, Bari, Italy.
Emilia RuggieroResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Amalia De CurtisResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Sara MagnaccaResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Mariarosaria PersichilloResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Francesc Casanovas-GarrigaDepartment of Internal Medicine, Hospital Clínic de Barcelona, University of Barcelona (UB), Barcelona, Spain.
Chiara CerlettiResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Maria Benedetta DonatiResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Giovanni de GaetanoResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Licia IacovielloResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.
Marialaura BonaccioResearch Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Isernia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate the association between wine consumption and biological aging in the Moli-sani Study. Methods: Dietary data were assessed using a 188-item FFQ. Participants (n = 22,495) were classified as abstainers, former drinkers, moderate drinkers according to national guidelines (≤250 mL/d men; ≤125 mL/d women) or Mediterranean Diet (MD) (125-500 mL/d men; 62.5-250 mL/d women), and heavy drinkers (>500 mL/d men; >250 mL/d women). Biological age (BA) was estimated with a deep neural network using 36 circulating biomarkers, and Δage (BA-chronological age) served as an index of biological aging. Results: In men, wine consumption, at doses defined moderate by a current MD Score, was associated with slower biological aging (Δage β = -0.39; 95%CI: -0.78, -0.01 vs. abstainers). Dose-response analyses showed a J-shaped curve, with the slowest Δage at ∼170 mL/d (Δage = -0.34 years; 95%CI: -0.66, -0.03). Overall ethanol intake, including all alcoholic beverages consumed, was neutral at moderate levels and associated with faster biological aging at higher doses. Conclusion: Moderate wine consumption, but not overall ethanol intake, may contribute to slower biological aging in men.

Indexed as

AgingAlcohol DrinkingDiet, MediterraneanWineAdultAgedBiomarkersFemaleHumansItalyMaleMiddle AgedSurveys and QuestionnairesBiomarkersbiological agingmediterranean dietneurological declinepreventionwine consumption

Identifiers

PMID41918706
PMCPMC13033601

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.