Evidence map›Paper›PMID 41918804›Full record

ArticleOncology letters2026

Methylglyoxal-derived glycated albumin enhances the stemness potential of invasive ductal carcinoma-derived breast cancer stem-like cell line KAIMRC1.

Maram Aldawood, Mariam K Alamoudi, Abdulmonem A Alsaleh, Nouf Alharbi, Sarah Huwaizi, Rehab Alroshody, Rizwan Ali, Rafa Almeer, Sabine Matou-Nasri

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Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maram AldawoodZoology Department, King Saud University, Riyadh 11451, Saudi Arabia.
Mariam K AlamoudiDepartment of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Abdulmonem A AlsalehBlood and Cancer Research Department, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
Nouf AlharbiMedical Genomics Research Department, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
Sarah HuwaiziMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
Rehab AlroshodyBlood and Cancer Research Department, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
Rizwan AliKing Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Rafa AlmeerZoology Department, King Saud University, Riyadh 11451, Saudi Arabia.
Sabine Matou-NasriBlood and Cancer Research Department, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a risk factor for breast cancer (BC) development and recurrence due to multifactorial mechanisms, including the generation of glycated proteins under hyperglycemic conditions. Emerging evidence indicates that hyperglycemia promotes the formation and expansion of BC stem-like cells (BCSC), contributing to worse outcomes in patients with T2DM. To support early detection and personalized therapy, there is an urgent need to identify novel biomarkers that specifically target BCSCs in patients with T2DM. The present study examined the effects of glycated albumin (GA) on the cellular functions of KAIMRC1, a naturally immortalized BCSC line derived from invasive ductal carcinoma (IDC), the primary breast carcinoma developed in patients with T2DM. Cells were subjected to

Indexed as

cancer stem-like cellsglycated albumininvasive ductal carcinomatriple-negative breast cancertype 2 diabetes mellitusvimentin

Identifiers

PMID41918804
PMCPMC13034109

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.