Disulfiram Exhibits Potent Copper-Dependent Antimicrobial Activity Against

Li Xiao, Grayson R Gimblet, Suzanne E Lapi, William M Geisler, James Daubenspeck, T Prescott Atkinson

Abstract read

In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li XiaoDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-0188-4023

Grayson R GimbletDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

William M GeislerDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0002-0603-2404

James DaubenspeckDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

T Prescott AtkinsonDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-2528-6976

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Minimum inhibitory concentration was performed via standard methods for human mycoplasmas and ureaplasmas as established by guideline M43-A of the Clinical and Laboratory Standards Institute. Mgen strain G37 was used as a part of a colorimetric checkboard assay to explore the mechanism of growth inhibition with DS, with emphasis on the role of copper on DS antimicrobial activity. Trace concentrations of radioactive Results: DS exhibits in vitro antimicrobial activity against Mgen isolates with low minimum inhibitory concentration values, regardless of susceptibility to other antibiotics. Growth inhibition studies with DS demonstrated that antimicrobial activity is copper dependent. Studies with Conclusions: DS exhibits potent copper-dependent antimicrobial activity against Mgen. DS or a similar compound could be developed as therapy for drug-resistant Mgen infections.

Indexed as

copper-64disulfiram-copperdrug repurposingdrug resistanceMycoplasma genitalium

Identifiers

PMID41918852

DOI10.1093/ofid/ofag042

PMCPMC13035022

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.