Evidence map›Paper›PMID 41918978›Full record

ArticleDiabetology international2026

Heat shock protein 72 (HSP72) modulates glucagon secretion via JNK inhibition in pancreatic α-cells.

Takuro Watanabe, Tatsuya Kondo, Rintaro Yoshizumi, Nobukazu Miyakawa, Sayaka Kitano, Mary Ann Suico, Miki Sato, Masaji Sakaguchi, Motoyuki Igata, Takeshi Matsumura and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Takuro WatanabeDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Tatsuya KondoDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.ORCID 0000-0003-4830-8955
Rintaro YoshizumiDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Nobukazu MiyakawaDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Sayaka KitanoDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Mary Ann SuicoDepartment of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, 5-1 Oe, Chuo-Ward, Kumamoto, 862-0973 Japan.
Miki SatoDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Masaji SakaguchiDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Motoyuki IgataDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Takeshi MatsumuraDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Hirofumi KaiDepartment of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, 5-1 Oe, Chuo-Ward, Kumamoto, 862-0973 Japan.
Eiichi ArakiDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.
Naoto KubotaDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ward, Kumamoto, 860-8556 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat shock protein 72 (HSP72) plays a protective role against metabolic stress through suppression of c-Jun N-terminal kinase (JNK). While HSP72 has been extensively studied in insulin-sensitive tissues and pancreatic β-cells, its role in regulating glucagon secretion in α-cells remains unclear. Because glucagon secretion is enhanced by stress-responsive kinases including JNK, we hypothesized that HSP72 may negatively regulate glucagon secretion. To evaluate the effects of HSP72 on glucagon regulation, HSP72 induction was achieved using a combination of heat shock (HS) and mild electrical stimulation (MES) in Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-026-00886-6.

Indexed as

DiabetesGlucagonHSP72Insulin signalingJNKα-cell

Identifiers

PMID41918978
PMCPMC13033473

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.