Evidence map›Paper›PMID 41919068›Full record

ArticleTherapeutic advances in neurological disorders2026

Insights into adherence to cladribine tablets in the real world in multiple countries: results from patient support programs.

Jiwon Oh, Mavis Ayer, Raed Alroughani, Samar Farouk, Mounir Khoury, Sabrina de Souza, Michela Bossolasco, Kate Morgan, Laura Negrotto, Tracey Quinn and 7 more

Abstract read
In one paragraph

Article in Therapeutic advances in neurological disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiwon OhDivision of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-5519-6088
Mavis AyerSouthampton General Hospital, Southampton, UK.
Raed AlroughaniDivision of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait.ORCID https://orcid.org/0000-0001-5436-5804
Samar FaroukDivision of Neurology, Department of Medicine, Ibn Sina Hospital, Kuwait City, Kuwait.
Mounir KhouryDivision of Neurology, Department of Internal Medicine, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon.
Sabrina de SouzaMerck Healthcare KGaA, Darmstadt, Germany.
Michela BossolascoEMD Serono, Inc., Mississauga, ON, Canada, an affiliate of Merck KGaA.
Kate MorganMerck Serono Ltd, Feltham, UK, an affiliate of Merck KGaA.
Laura NegrottoMerck S.A., Buenos Aires, Argentina, an affiliate of Merck KGaA.
Tracey QuinnMerck Healthcare Pty. Ltd, Macquarie Park, NSW, Australia, an affiliate of Merck KGaA.
Amir BoshraMerck Serono Middle East FZ-Ltd, Dubai, United Arab Emirates, an affiliate of Merck KGaA.
Joseph YoussefMerck Serono Middle East FZ-Ltd, Dubai, United Arab Emirates, an affiliate of Merck KGaA.
Murad Al-NaqshbandiMerck Serono Middle East FZ-Ltd, Dubai, United Arab Emirates, an affiliate of Merck KGaA.
Kelly MacDonaldEMD Serono Inc., Boston, MA, USA, an affiliate of Merck KGaA.
Meritxell SabidóMerck Healthcare KGaA, Frankfurter Str. 250, Darmstadt 64293, Germany.ORCID https://orcid.org/0000-0002-4281-6759
Jeffrey M MuirMarket Access & Health Economics, Cytel, Inc., Toronto, ON, Canada.
Berenice SilvaDepartment of Neurology, Italian Hospital of Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0001-5866-2419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patient support programs (PSP) help initiate and maintain disease-modifying treatment (DMT) for people with multiple sclerosis (PwMS). adveva Objective: To evaluate initiation and completion of short courses of cladribine tablets treatment in Years 1 and 2 for PwMS and the frequency of subsequent treatment. Design: Retrospective, multinational, observational study using real-world data from PSPs. Methods: Clinical data from PSPs in Australia, Canada, Gulf, Latin America, Near East, Netherlands, UK, and US (December 2017-December 2023) included prior DMT use, cladribine tablets initiation and completion (Years 1 and 2), and subsequent treatment after Year 2 for those with ⩾48 months' follow-up. Results: Across all PSPs, 22,082 PwMS initiated cladribine tablets (Australia, Conclusion: Cladribine tablets adherence was high, with most PwMS completing short-course cladribine tablets treatment in Years 1 and 2. Of those with ⩾48 months' follow-up, only a small proportion received additional cladribine tablets treatment.

Indexed as

additional treatmentcladribine tabletspatient support program

Identifiers

PMID41919068
PMCPMC13033868

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.