Evidence mapPaperPMID 41919213Full record

ArticleRSC advances2026

Multitarget synthetic piperates against key drug targets of Alzheimer's and diabetes mellitus.

Asif Ahmad, Uzma Salar, Musa Özil, Nimet Baltaş, Maria Nasim, Aaqib Ullah, Zaheer Ul-Haq, Khalid Mohammed Khan, Farzana Shaheen

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Asif AhmadThird World Center for Science and Technology, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi Karachi 75270 Pakistan farzana.shaheen@iccs.edu +92-21111222292 ext. 136.
Uzma SalarDr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi Karachi-75270 Pakistan uzma_salar_sheikh@hotmail.com uzma.salar@iccs.edu.ORCID https://orcid.org/0000-0003-1871-9112
Musa ÖzilDepartment of Chemistry, Recep Tayyip Erdogan University 53100 Rize Turkey.ORCID https://orcid.org/0000-0002-1980-1364
Nimet BaltaşDepartment of Chemistry, Recep Tayyip Erdogan University 53100 Rize Turkey.
Maria NasimDr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi Karachi-75270 Pakistan uzma_salar_sheikh@hotmail.com uzma.salar@iccs.edu.
Aaqib UllahThird World Center for Science and Technology, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi Karachi 75270 Pakistan farzana.shaheen@iccs.edu +92-21111222292 ext. 136.
Zaheer Ul-HaqDr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi Karachi-75270 Pakistan uzma_salar_sheikh@hotmail.com uzma.salar@iccs.edu.
Khalid Mohammed KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi Karachi 75270 Pakistan.
Farzana ShaheenThird World Center for Science and Technology, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi Karachi 75270 Pakistan farzana.shaheen@iccs.edu +92-21111222292 ext. 136.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A library of piperate derivatives 3-25 was synthesized in a two-step reaction scheme starting from piperine 1, which was converted to piperic acid 2 first, and then reacted with various alkyl and aryl halides to afford the final products. Compounds were fully characterized and evaluated for their multitarget potential against well-established drug targets involved in diabetes and Alzheimer's diseases.

Identifiers

PMID41919213
PMCPMC13034056

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.