ArticleFrontiers in oncology2026
HPV6-associated cervical squamous cell carcinoma: a case report and literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Low-risk human papillomavirus (HPV) types are traditionally regarded as non-oncogenic and are primarily associated with benign epithelial proliferations. Invasive cervical squamous cell carcinoma (CSCC) related to low-risk HPV infection is exceedingly rare. Here, we report a rare case of HPV6-associated CSCC in a postmenopausal woman and comprehensively characterize its clinicopathological, immunophenotypic, and molecular features, with a review of the relevant literature. The patient presented with irregular vaginal bleeding and an exophytic cervical mass. Histopathological examination revealed verrucous papillary squamous epithelial hyperplasia with prominent fibrovascular cores, surface koilocytosis, marked cytological atypia, and focal superficial stromal invasion (≤ 3 mm). Immunohistochemical analysis demonstrated negative p16 expression and a high Ki67 proliferation index. HPV genotyping detected isolated low-risk HPV type 6, with no evidence of high-risk HPV infection. Targeted next-generation sequencing identified multiple somatic alterations, including pathogenic mutations in
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