ArticleBrazilian oral research2026
Characterization of bovine-teeth nanoparticles and its effect on BMP-2 expression in periodontitis rat model.
Article in Brazilian oral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine teeth-derived nanoparticles show strong potential in regenerating alveolar bone tissue damaged by periodontitis. They possess osteoinductive and osteoconductive properties that stimulate cell differentiation, proliferation, and extracellular matrix formation. This study characterized nanoparticles from bovine teeth and evaluated their potential for alveolar bone regeneration via particle size analysis, transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray fluorescence (XRF), Brunauer-Emmett-Teller (BET) analysis, micro-computed tomography, and Fourier-transform infrared spectroscopy (FTIR). Twenty Wistar rats were divided into four groups: one control and three treatment groups, which were observed on days 7, 14, and 28. The rats were injected with lipopolysaccharides from Porphyromonas gingivalis to create a model of periodontitis model. Bovine teeth nanoparticles were applied to the periodontal pockets and covered with a periodontal dressing. The particle sizes ranged from 3.67 to 36.75 nm. TEM images revealed that the particles were spherical, while XRD analysis showed that the components consisted of 63% hydroxyapatite and 37% whitlockite. XRF analysis showed that the mineral content was highest in calcium (81.96%) and phosphorus (15.90%). BET analysis indicated that the characteristics of the nanoparticle material were similar to those of commercial bovine bone material. FTIR analysis revealed the presence of hydroxyapatite groups, including -OH, H2O, and P-4. BMP-2 expression levels were notably higher in the repaired bone on day 28 than on days 7 and 14. In conclusion, bovine teeth-derived nanoparticles demonstrate significant potential as biomaterials for alveolar bone regeneration in periodontitis therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.