Evidence map›Paper›PMID 41920118›Full record

ArticleJACC. Asia2026

Blood Pressure Reduction Effects of Salt Substitutes in Different Application Settings A Meta-Analysis of Randomized Controlled Trials.

Xianghui Zhang, Yifang Yuan, Chao Gao, Xuejun Yin, Yufei Ji, Xizi Zheng, Qi Zhou, Yangfeng Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xianghui ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Shihezi University, Shihezi, China.
Yifang YuanClinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China.
Chao GaoNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Xuejun YinSchool of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yufei JiFuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Xizi ZhengRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China.
Qi ZhouEvidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Yangfeng WuClinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China. Electronic address: wuyf@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeta-analysis has been performed on the blood pressure-lowering effect of salt substitutes; however, whether the effects vary by application setting remains unclear.

objectivesThis study aims to compare the blood pressure-lowering effect of salt substitution between home-cooking and collective-cooking settings.

methodsWe searched PubMed, EMBASE, the Cochrane Library, CNKI, and WanFang databases for randomized controlled trials (RCTs) comparing salt substitutes with usual salt on blood pressure, with the last search on June 3-4, 2025. Meta-analysis stratified by application setting was performed.

resultsParticipants (N = 29,570) in 21 RCTs (n = 27,813 participants in 18 RCTs with home-cooking and n = 1,757 participants in 3 RCTs with collective-cooking) were included for analysis. Salt substitutes significantly reduced systolic blood pressure (SBP) by 4.7 mm Hg (95% CI: -5.7 to -3.6; I

conclusionsReplacing usual salt with salt substitutes lowered blood pressure more in the collective-cooking than the home-cooking setting, suggesting that public health policies and strategies should be developed to prioritize full adoption of salt substitutes to maximize its health benefits.

Indexed as

application settingblood pressuremeta-analysissalt substitutes

Identifiers

PMID41920118
PMCPMC13350103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.