ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026
The Phylum Fusobacteriota Is Associated with Colorectal Cancer-Specific Mortality: Results from the Translational Research Program in Cancer Differences across Populations.
Claire E Thomas, Nicole C Loroña, Scott D LaBrie, Keith R Curtis, Hang Yin, Ningxin Ma, Timothy W Randolph, Conghui Qu, Jeroen R Huyghe, Sushma Thomas and 13 more
Abstract read
In one paragraphArticle in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
23 authors.
Claire E Thomas *Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0000-0001-9515-3277 Nicole C Loroña *Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California.ORCID 0000-0002-8302-3157 Scott D LaBrie *Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0000-0003-0412-0731 Orsalem J KahsaiPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0009-0008-1709-4257 Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0000-0003-1543-0743 Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California.ORCID 0000-0001-8040-3341 Meredith A J HullarPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.ORCID 0000-0002-5322-9568 Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MTranslational Research Program in Cancer Differences across PopulationsP50CA285275 · NCI · FRED HUTCHINSON CANCER CENTER · PI AMANDA L KOEHNE · 2024 to 2026
$9.9MAdding Hispanics to Ongoing GWAS in Colorectal CancerR01CA155101 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FIGUEIREDO, JANE C. · 2011 to 2015
$4.5MContributing Factors and Consequences of Cancer Health DisparitiesT32CA094880 · NCI · UNIVERSITY OF WASHINGTON · PI Christopher I Li, AMANDA IRENE PHIPPS · 2017 to 2026
$3.7MVariation in tumor-associated immune profiles and colorectal cancer outcomesR01CA248931 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI SCHMIT, STEPHANIE L. · 2021 to 2025
$3.5MTranslational Research Program in Colorectal Cancer DisparitiesP20CA252733 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I · 2020 to 2022
$3.4MBiological determinants of colorectal cancer outcomes in Latinos of diverseýancestral originsR01CA238087 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI FIGUEIREDO, JANE C., SCHMIT, STEPHANIE L. · 2019 to 2024
$3.2MDeep molecular and cellular profiling of colorectal cancer tumor and immune microenvironment in Alaska Native peopleR01CA280639 · NCI · FRED HUTCHINSON CANCER CENTER · PI Jeroen R Huyghe, ULRIKE PETERS · 2023 to 2026
$2.8MElucidating the role of transcriptomics in driving ethnicity and ancestry-related disparities in colorectal cancerR01CA284732 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Jane C. Figueiredo, Jennifer Ann Freedman · 2024 to 2026
$2.0MBuilding a Cancer Epidemiology Cohort to Investigate Factors Associated with Higher Risk of Colorectal Cancer among Alaska Native PeopleU01CA290673 · NCI · ALASKA NATIVE TRIBAL HEALTH CONSORTIUM · PI DIANA REDWOOD · 2024 to 2026
$1.3MGoldman Sachs FoundationNational Institutes of Health (NIH) P20CA252733National Institutes of Health (NIH) P50CA285275National Institutes of Health (NIH) R01CA155101National Institutes of Health (NIH) R01CA238087National Institutes of Health (NIH) R01CA248931National Institutes of Health (NIH) R01CA280639National Institutes of Health (NIH) R01CA284732National Institutes of Health (NIH) T32CA094880National Institutes of Health (NIH) U01CA290673NCI NIH HHS P20 CA252733NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA285275NCI NIH HHS R01 CA155101NCI NIH HHS R01 CA238087NCI NIH HHS R01 CA248931NCI NIH HHS R01 CA280639NCI NIH HHS R01 CA284732NCI NIH HHS T32 CA094880NCI NIH HHS U01 CA290673V Foundation
6 · The paper itselfAbstract
backgroundThe microbiome is an important component of the tumor microenvironment implicated in colorectal cancer. However, its relationship with colorectal cancer-specific mortality remains unclear.
methodsWe included 581 participants with colorectal cancer (167 African American, 176 Alaska Native, 118 Hispanic, and 120 non-Hispanic White) from the Translational Research Program in Cancer Differences across Populations (TRPCDP). We sequenced the V4 region of the 16S rRNA bacterial gene using DNA extracted from formalin-fixed, paraffin-embedded tumors. A total of 204 participants died of colorectal cancer and 377 did not die of colorectal cancer. Participants who died of colorectal cancer were matched to participants who did not die of colorectal cancer during follow-up by age, sex, tumor site, tumor stage, year of diagnosis, and population group. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (CI) for associations between bacterial presence and colorectal cancer-specific mortality, adjusting for matching factors and tissue macrodissection status.
resultsIndividuals who died from colorectal cancer were 1.71 times as likely to have bacteria from the Fusobacteriota phylum present in their tumors (OR = 1.71; 95% CI = 1.19-2.47). Associations with Fusobacteriota were strongest among African American participants (OR = 2.36; 95% CI = 1.14-4.99) compared with other populations; however, this difference was not statistically significant (OR range = 1.05-1.38; Pinteraction = 0.697). Candidate pathways of pyruvate fermentation to acetate and lactate II and peptidoglycan biosynthesis I were associated with higher odds of colorectal cancer death.
conclusionsFusobacteriota was significantly associated with colorectal cancer-specific mortality with noted differences across populations. IMPACT: This finding highlights the tumor microbiome as a candidate for further investigation into colorectal cancer outcome disparities.
Indexed as
Colorectal NeoplasmsMicrobiotaAgedAged, 80 and overAlaska NativesBlack or African AmericanFemaleHispanic or LatinoHumansMaleMiddle AgedRNA, Ribosomal, 16STranslational Research, BiomedicalWhiteRNA, Ribosomal, 16S
Identifiers
PMID41920180
PMCPMC13587923
What Socratic holds
Textmetadata
Read underepoch 390