ArticleSports medicine (Auckland, N.Z.)2026
Physiological Outcomes of Physical Activity Interventions in Persistent Postconcussive Symptoms: A Scoping Review.
Article in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
backgroundPersistent postconcussive symptoms (PPCS) are associated with prolonged functional impairment and physiological dysregulation following mild traumatic brain injury, yet objective markers of recovery and treatment response remain limited.
objectiveThe objective of this review was to synthesize the impact of aerobic exercise on physiological alterations in PPCS.
methodsThis paper is a scoping review reported in accordance with PRISMA-ScR. A protocol was published in advance, with the last search conducted on 31 May 2025. This review scanned the following databases: PubMed, MEDLINE, EMBASE, Cochrane Library, Web of Science, and Scopus. Eligible studies were original human studies with clinically diagnosed persistent postconcussive symptoms or mild traumatic brain injury that implemented a physical activity or aerobic exercise intervention and reported at least one physiological outcome (e.g., blood pressure, cerebrovascular indices, or heart rate variability). The exclusion criteria were as follows: moderate/severe traumatic brain injury, self-reported concussion without clinical diagnosis, non-English studies, animal studies, and review papers.
resultsOf 1451 papers found, five were eligible. Individualized sub-symptom-threshold aerobic exercise consistently improved exercise tolerance and heart rate thresholds; several studies showed normalization of exertional blood pressure responses and improved CO
conclusionsAerobic exercise yields physiological benefits in PPCS and is actionable for management and progression. Future studies should standardize physiological endpoints, include underrepresented populations, and test predictive markers to allow for precise rehabilitation.
Indexed as
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Registered trials
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