SynthesisPediatric radiology2026
Dynamic contrast-enhanced magnetic resonance imaging in paediatric brain tumours systematically reviewed.
Synthesis in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Efficacy of chemoradiotherapy in pediatric H3K27M-mutant diffuse intrinsic pontine glioma: a study based on single-center and SEER data.Journal of neuro-oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundDynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is an advanced imaging technique that quantifies blood-brain permeability using dynamic contrast uptake.
objectiveThe clinical utility of DCE in paediatric brain tumours is unclear. This systematic review evaluates the efficacy of DCE for tumour differentiation and progression assessment in paediatric brain tumours, and summarises current technical implementation to inform clinical practice. MATERIALS AND
methodsA string-based literature search was performed in PubMed and Web of Science. Original articles evaluating the utility of DCE were included. A modified quality assessment of diagnostic accuracy studies-2 (QUADAS-2) instrument evaluated the risk of bias.
resultsNine studies (2008-2025) were eligible (sample size 6-72 cases). Six studies investigated low-grade versus high-grade differentiation in mixed paediatric tumours (cumulative sample n=196) with successful discrimination through K
conclusionDCE may be of added value to discriminate between two different paediatric brain tumour entities, but a general discrimination potential between low- and high-grade lesions is doubtful. More studies and greater technical homogeneity are needed to investigate the technique's prognostic potential for paediatric cohorts.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.