In one paragraphArticle in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
22 authors.
Ryan A DohoneyDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0000-0002-0190-8665 L PalanikumarBiology Program, Division of Science, New York University Abu Dhabi, PO Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.ORCID 0000-0002-2639-0436 Emily OldaniDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0009-0006-5430-0270 Charles Zuwu BaysahDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0000-0003-0657-0461 Johnson A JosephDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0000-0002-0415-3122 David PolancoInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Department of Biochemistry and Molecular and Cellular Biology, University of Zaragoza, Zaragoza 50009, Spain.ORCID 0000-0002-0005-6712 Paula Santos-OtteMax Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin 10115, Germany.ORCID 0009-0009-4556-0574 Nicholas H StillmanDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0000-0002-8353-7684 Peter CorcoranDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.
Tyler D BallDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0000-0001-9602-0329 Tessa C FitchKnoebel Institute for Healthy Aging, 2155 E. Wesley Ave., Suite 579, University of Denver, Denver, CO 80208, USA.
Jemil AhmedKnoebel Institute for Healthy Aging, 2155 E. Wesley Ave., Suite 579, University of Denver, Denver, CO 80208, USA.
Ifunayachi Ogbonna-UkukuDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0009-0001-3818-5421 Kevin M Reynolds CaicedoKnoebel Institute for Healthy Aging, 2155 E. Wesley Ave., Suite 579, University of Denver, Denver, CO 80208, USA.ORCID 0009-0000-4688-0144 Ying LiuDepartment of Neurology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO 80045, USA.
Maureen A LeeheyDepartment of Neurology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO 80045, USA.
Daniel A LinsemanKnoebel Institute for Healthy Aging, 2155 E. Wesley Ave., Suite 579, University of Denver, Denver, CO 80208, USA.ORCID 0000-0001-8774-1976 Daniel A ParedesKnoebel Institute for Healthy Aging, 2155 E. Wesley Ave., Suite 579, University of Denver, Denver, CO 80208, USA.ORCID 0000-0002-9635-8001 Melissa BirolMax Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin 10115, Germany.ORCID 0000-0003-3397-8446 Nunilo CremadesInstitute for Biocomputation and Physics of Complex Systems (BIFI) and Department of Biochemistry and Molecular and Cellular Biology, University of Zaragoza, Zaragoza 50009, Spain.ORCID 0000-0002-9138-6687 Mazin MagzoubBiology Program, Division of Science, New York University Abu Dhabi, PO Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.ORCID 0000-0003-3414-6617 Sunil KumarDepartment of Chemistry and Biochemistry, F. W. Olin Hall, 2190 E. Iliff Ave., University of Denver, Denver, CO 80210, USA.ORCID 0000-0001-5472-4619 Funding
Synthetic protein mimetics as potential therapeutics for Lewy Body DementiaR61NS137824 · NINDS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI Sunil Kumar · 2024 to 2026
$1.8M120 kV Transmission Electron Microscope for CU Anschutz Electron Microscopy Core FacilityS10OD036258 · OD · UNIVERSITY OF COLORADO DENVER · PI FARHANG DAREHSHOURI, ANZA · 2024 to 2024
$678kNIH HHS S10 OD036258NINDS NIH HHS R61 NS137824
6 · The paper itselfAbstract
Synucleinopathies is an umbrella term for multiple neurological disorders, including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). A central pathological hallmark of synucleinopathies is the aggregation of α-synuclein (αS, a neuronal protein) and its prion-like spread. Therefore, inhibition of αS aggregation and spread is considered a viable therapeutic approach for the treatment of synucleinopathies. Foldamers are synthetic ligands that mimic the secondary structure of proteins. Using an oligoquinoline (OQ) scaffold-based foldamer approach, we have previously identified a foldamer (SK-129) that potently inhibits αS aggregation. Here, using a wide range of biophysical, cellular, and in vivo methods, we showed that SK-129 rescued synucleinopathy phenotypes in cellular,
Indexed as
Synucleinopathiesalpha-SynucleinAnimalsBlood-Brain BarrierCaenorhabditis elegansDisease Models, AnimalHumansInduced Pluripotent Stem CellsMiceNeuronsPhenotypealpha-Synuclein
Identifiers
PMID41920967
PMCPMC13430570
What Socratic holds
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LicenceTDM
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