Evidence map›Paper›PMID 41920984›Full record

ArticleScience advances2026

Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophages.

Jordan C Rozum, William Sineath, Pavlo Bohutskyi, Jordan Quenneville, Doo Nam Kim, Connah Johnson, Angad P Mehta, James Evans, David Pollock, Wei-Jun Qian and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dynamic metabolic modelling of ATP allocation during viral infection.Journal of the Royal Society, Interface · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jordan C RozumBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0002-4356-9809
William SineathBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0009-0007-4006-9482
Pavlo BohutskyiBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0002-0462-8132
Jordan QuennevilleDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0009-0000-1498-6614
Doo Nam KimBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0001-9895-7190
Connah JohnsonAdvanced Computing, Mathematics, and Data Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0002-4672-9628
Angad P MehtaDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0003-2585-8268
James EvansEnvironmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0002-7721-4782
David PollockBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Wei-Jun QianBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0002-5393-2827
Margaret S CheungEnvironmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0001-9235-7661
Ruonan WuBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0001-9466-4462
Song FengBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0003-3983-9009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteriophage auxiliary metabolic genes (AMGs) alter host metabolism by hijacking reactions, but previous studies mostly inferred their roles from annotations, ignoring system-wide impacts and phage production. Here we integrate AMGs and phage assembly into a genome-scale metabolic model of

Indexed as

BacteriophagesGenome, BacterialModels, BiologicalProchlorococcusMetabolic Networks and PathwaysSynechococcus

Identifiers

PMID41920984
PMCPMC13041748

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.