ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026
Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study.
Abstract readMulticenter Study
In one paragraph
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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What it found
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The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
52 authors.
Elise A MitriCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0002-1250-2847
Sara VogrinCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0002-1597-9421
Camille PaynterSchool of Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Luke R FletcherDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia.
Jonny PeterAllergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
Neil PowellPharmacy Department, Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom.
Sara BarnesMonash Lung Sleep Allergy and Immunology, Monash Health, Clayton, Victoria, Australia.
Philip H LiDivision of Rheumatology & Clinical Immunology, Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0002-9155-9162
Ana Maria CopaescuCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0002-9183-5032
Nicholas A TurnerDivision of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0003-0650-4894
Fiona JamesCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.
Richard SullivanDepartment of Infectious Diseases, St George Hospital, School of Clinical Medicine, UNSW Medicine and Health, Kogarah, New South Wales, Australia.ORCID 0000-0001-7176-1673
Maryam Sherkat MasoumDepartment of Pharmacy and Department of Infectious Diseases, Royal Perth Hospital, Perth, Western Australia, Australia.ORCID 0000-0003-2784-8813
Matthew RawlinsDepartment of Pharmacy, Fiona Stanley Hospital, Perth, Western Australia, Australia.ORCID 0000-0002-6525-1084
Geoff MackayDepartment of Pharmacy, Albury Wodonga Health, Albury, New South Wales, Australia.
Benjamin J SmithDepartment of Infectious Diseases, Western Health, Footscray, Victoria, Australia.ORCID 0009-0004-6214-5923
Patricia KilfoylePharmacy Department, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.ORCID 0009-0004-5734-8056
Daniel ForsterDepartment of Infectious Diseases, Eastern Health, Box Hill, Victoria, Australia.ORCID 0009-0001-5437-867X
Morgan RoseCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0001-8714-5998
Raquel CowanInternal Medical Services, Grampians Health Service, Ballarat, Victoria, Australia.
Kylie AlcornDepartment of Infectious Diseases, Gold Coast Hospital and Health Service, Gold Coast, Queensland, Australia.ORCID 0000-0003-2591-483X
Anna BrischettoInfectious Diseases Unit, Redcliffe Hospital, Brisbane, Queensland, Australia.
Andrew MahonyDepartment of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-9027-5539
Andrew RedmondInfectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-1125-5362
Arindam ChakravortyInfectious Diseases and General Medicine, St John of God Subiaco, Perth, Western Australia, Australia.ORCID 0000-0002-8880-7516
Zaal Meher-HomjiDepartment of Medicine, Latrobe Regional Health, Traralgon, Victoria, Australia.
Chino YusonDepartment of Clinical Immunology and Allergy, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Simeon CrawfordDepartment of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.ORCID 0000-0003-3104-1289
Greg WeeksPharmacy Department, Barwon Health, Geelong, Victoria, Australia.ORCID 0000-0001-8775-1461
Sasheela Sri La Sri PonnampalavanarInfectious Disease Unit, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603,Malaysia.ORCID 0000-0002-4506-1304
Constance KatelarisImmunology/Allergy Unit, Department of Medicine, Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia.ORCID 0000-0002-4412-1336
Priscilla TranDepartment of Pharmacy, Campbelltown Hospital, Sydney, New South Wales, Australia.
Jennifer O'HernDepartment of Infectious Diseases, Launceston General Hospital, Launceston, Tasmania, Australia.ORCID 0000-0003-3899-8956
Jack GodsellCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.
Trisha N PeelDepartment of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-2370-2438
Indy SandaraduraCentre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.ORCID 0000-0002-9457-8262
David NewDepartment of Infectious Diseases, Armadale Health Service, Perth, Western Australia, Australia.ORCID 0000-0002-1299-8117
Candice HollandDepartment of Infectious Diseases, Ipswich Hospital, Ipswich, Queensland, Australia.
Tim CutfieldDepartment of Infectious Diseases, Middlemore Hospital, Auckland, New Zealand.ORCID 0000-0002-3995-1984
Sarah CoghillDepartment of Infectious Diseases, Lismore Base Hospital, Lismore, New South Wales, Australia.
Caitlin HandPharmacy Department, Mildura Base Public Hospital, Mildura, Victoria, Australia.
Jacob WilliamsDepartment of Infectious Diseases, Orange Health Service, Orange, New South Wales, Australia.ORCID 0000-0003-1492-9390
Jaclyn BishopDevelopment & Improvement, East Grampians Health Service, Ararat, Victoria, Australia.
Belinda LambrosDepartment of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Cascia DayAllergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.ORCID 0000-0002-8090-3861
Courtney IeranoDepartment of Infectious Diseases, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-5472-8895
Natasha E HolmesCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0001-8501-4054
Jason A RobertsUniversity of Queensland Centre for Clinical Research, Faculty of Health Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queenland, Australia.
Suran L FernandoDepartment of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Marlena KlaicSchool of Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-2328-0503
Jason A TrubianoCentre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.ORCID 0000-0002-5111-6367
International Network of Antibiotic Allergy Nations (iNAAN) study group
Funding
Advancing Queensland Clinical FellowshipAustralian GovernmentMurdoch Children's Research Institute (MCRI)National Allergy Centre of Excellence (NACE)National Health and Medical Research Council (NHMRC)NHMRC Centre of Research ExcellenceNHMRC Investigator GrantVictorian Government's Operational Infrastructure Support Program
Abstract
In this international, multicenter prospective study, implementing penicillin direct oral challenge (DOC) using a digital toolkit was acceptable, feasible, and sustainable. Audit and feedback increased activity, particularly among pharmacists. Safety was maintained across heterogeneous DOC protocols, validating a pragmatic, scalable approach that supports local adaptation.
Indexed as
Anti-Bacterial AgentsDrug HypersensitivityPenicillinsAdministration, OralAntimicrobial StewardshipHospitalsHumansProspective StudiesAnti-Bacterial AgentsPenicillinsantimicrobial stewardshipaudit and feedbackimplementationoral challengepenicillin allergy
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.