Evidence map›Paper›PMID 41921770›Full record

ArticleThe Journal of pediatrics2026

The Effect of Anemia on Mortality in Children Hospitalized with Severe Pneumonia in Uganda.

Peter P Moschovis, Amal Sharfi, Sumona Chaudhury, Ashley Sharma, Matthew O Wiens, Elias Kumbakumba, Olive Keneema, Dan Nyehengane, Jerome Kabakyenga, J Mark Ansermino and 5 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02466672 (The Role and Effect of Anemia in Children With Pneumonia), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02466672 completednot on this map

The Role and Effect of Anemia in Children With Pneumonia

TypeobservationalSponsorMassachusetts General HospitalRan2015 to 2016Enrolled212ConditionsAnemia, PneumoniaArmsnone - observational only
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peter P MoschovisDepartment of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: pmoschovis@mgh.harvard.edu.
Amal SharfiDepartment of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Sumona ChaudhuryDepartment of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Ashley SharmaDepartment of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Matthew O WiensBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Elias KumbakumbaDepartment of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Olive KeneemaDepartment of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda; Holy Innocents Children's Hospital, Mbarara, Uganda.
Dan NyehenganeEpicentre Uganda Research Centre, Mbarara, Uganda.
Jerome KabakyengaDepartment of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda.
J Mark AnserminoBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Niranjan KissoonBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
David C ChristianiDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Walter DzikDepartment of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Julius P KiwanukaDepartment of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Patricia L HibberdDepartment of Global Health, Boston University School of Public Health, Boston, Massachusetts.

Funding

Midcareer Investigator Award in Patient-Oriented Research (K24)K24AT003683 · NCCIH · TUFTS MEDICAL CENTER · PI HIBBERD, PATRICIA L · 2006 to 2015
$1.9M
The effect of household air pollution on lung function growth in infants with pneumonia in sub-Saharan Africa.K23ES030399 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSCHOVIS, PETER P · 2019 to 2024
$1.1M
Optimizing air purification strategies to reduce household PM2.5 exposure in UgandaR21ES036797 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSCHOVIS, PETER P · 2024 to 2025
$474k
The Role and Consequences of Anemia in Children with PneumoniaF32HL124951 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MOSCHOVIS, PETER P · 2014 to 2016
$161k
NCCIH NIH HHS K24 AT003683NHLBI NIH HHS F32 HL124951NIEHS NIH HHS K23 ES030399NIEHS NIH HHS R21 ES036797
6 · The paper itself

Abstract

objectiveTo examine the effect of anemia on mortality among children hospitalized with severe pneumonia in Uganda. STUDY

designThis prospective cohort study enrolled children aged 6 to 59 months admitted with severe pneumonia to 2 hospitals in western Uganda. Severe pneumonia was diagnosed based on World Health Organization criteria, and anemia was diagnosed by hemoglobin (Hb) measured at admission.

resultsAmong 212 children with severe pneumonia, with a median age of 13.3 months, 67.5% had at least mild anemia (Hb < 11 g/dL) and 9.0% had severe anemia (Hb < 7 g/dL). A lower mean Hb was observed among children who died during hospitalization (8.5 vs 10.2 g/dL; mean difference 1.7 g/dL [95% CI: 0.6, 2.7]). Adjusting for age and oxygen saturation, Hb concentration was inversely associated with mortality. For every 1 g/dL increase in Hb, we observed a 28% lower odds of death (OR: 0.72 [95% CI: 0.57, 0.89]). We also calculated the product of Hb and oxygen saturation (saturated Hb); no child with a saturated Hb > 12 g/dL died, compared with 28% of children with saturated Hb < 6 g/dL.

conclusionsAmong children hospitalized with severe pneumonia, a dose-dependent and independent association was observed between anemia and risk of mortality, with an even greater effect among children with hypoxemia. Public health and clinical interventions that target prevention, early detection, and prompt treatment of anemia may improve outcomes of children with pneumonia, particularly in low-income settings. CLINICAL

trial registrationNCT02466672 (observational study registration).

Indexed as

AnemiaPneumoniaChild, PreschoolFemaleHemoglobinsHospitalizationHospital MortalityHumansInfantMaleProspective StudiesSeverity of Illness IndexUgandaHemoglobinsanemiahypoxemiapneumonia

Identifiers

PMID41921770
PMCPMC13626033

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.