ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026
Small peptides derived from the autoinhibitory XY linker of phospholipase C-β isoforms inhibit enzyme activity and reduce inflammation.
Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Phospholipase C-β (PLCβ) signaling plays a pivotal role in peripheral nociception during inflammation and pain transduction. These enzymes are associated with G-protein coupled receptors of pro-inflammatory and algesic agents that sensitize nociceptors and promote their hyperexcitability. Despite their validation as therapeutic targets, PLCβ isoforms are yet considered undruggable due to the difficulties to identify potent and selective modulators. Here, we address this question and use the autoinhibitory XY linker present in these enzymes as a source of peptide inhibitors of PLCβ activity. We report that peptides patterned after this motif penetrate the cell membrane and interact with PLCβ3 to inhibit PIP
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