SynthesisJournal of clinical hypertension (Greenwich, Conn.)2026
The Optimal Dosage of Isometric Handgrip Exercise for Blood Pressure Reduction: Systematic Review and Meta-Analysis.
Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Rethinking Isometric Handgrip Exercise Prescription: A Commentary on Duration, Fatigue, and Blood Pressure Management.Health science reports · 2026Article
- Response to Letter to Editor "Effects of Intensity, Duration and Muscle Mass on Neuromuscular Fatigue and Blood Pressure After Isometric Handgrip Exercise".Health science reports · 2026Article
- Optimizing Isometric Handgrip Training for Hypertension: Insights and Gaps in Exercise Configuration.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Effects of the Intensity, Duration, and Muscle Mass of Isometric Handgrip Exercise on Neuromuscular Fatigue and Post-Exercise Blood Pressure Responses: A Crossover Study.Health science reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The systematic review and meta-analysis aimed to examine the dose-response relationship between isometric handgrip (IHG) training and blood pressure outcomes in normotensive and hypertensive populations. Three databases (EMBASE, MEDLINE/PubMed, and Cochrane CENTRAL) were searched from inception to June 2025. Thirty-one studies with 905 participants (51% male) met the criteria. Primary outcomes were resting systolic (SBP) and diastolic blood pressure (DBP). Study quality was assessed using the PEDro scale and RoB-2. Meta-regression was used to evaluate dose-response effects on SBP and DBP. The included studies demonstrated fair to good methodological quality (5.9 ± 1.0). Moderate evidence indicated that IHG reduced SBP (-5.38 mmHg, 95% CI -6.91 to -3.85; p < 0.001; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.