ArticleBDJ open2026
The association between systemic immune-inflammation index and periodontitis in adults with and without hyperlipidemia: a population-based study.
Article in BDJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association between SII and periodontitis, and to determine whether this association differs by hyperlipidemia status in adults.
methods21,283 U.S. adults aged ≥18 years were enrolled from NHANES 1999-2014. Multivariable logistic regression models were employed to assess the association between SII and periodontitis while controlling for potential confounding factors. We further explored non-linear dose-response relationships using two-piecewise regression model to identify any threshold effect of SII on periodontitis risk. Robustness of the findings was evaluated through sensitivity analyses.
resultsPeriodontitis was prevalent in 6,758 individuals (31.75%). In stratified analyses, this pattern was evident among individuals with hyperlipidemia: we identified an inflection point at SII ≈ 522. Within the lower SII range, a 500-unit increment demonstrated an inverse association with periodontitis susceptibility, yielding a significant 18% risk reduction (OR = 0.82, 95% CI 0.68-0.99, P = 0.036). Conversely, in the upper SII spectrum, identical 500-unit increments corresponded to a substantial 15% heightened periodontitis risk (OR = 1.15, 95% CI 1.05-1.25, P = 0.002). A significant non-linear dose-response was found in hyperlipidemic individuals (P for threshold effect = 0.005). In contrast, among individuals without hyperlipidemia, no significant association between SII and periodontitis was detected. Sensitivity analyses, including the exclusion of participants with malignancies, stratification by sex and using alternative periodontitis definitions, yielded consistent results, reinforcing the robustness of our findings.
conclusionsSII demonstrated a non-linear association with periodontitis that was restricted to individuals with hyperlipidemia. In hyperlipidemic adults, moderate increases in SII (within a lower range) were associated with reduced odds of periodontitis, whereas an SII beyond ~522 was significantly associated with higher disease prevalence.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.