ArticleNature communications2026
Perinatal brain developmental transition revealed by transcriptomic and proteomic analyses of Bama miniature pigs.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- TH/TRs-COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
The perinatal period witnesses dynamic structural reorganization and functional specialization essential for establishing later-life neural circuitry integrity. However, molecular mechanisms governing spatiotemporal developmental trajectories during this critical window remain poorly characterized due to limited accessibility of human perinatal specimens. Here, we analysed transcriptomes and proteomes from 336 samples across multiple time points and brain regions in perinatal Bama miniature pigs, showing their spatiotemporal organization and concordance between genes and proteins. We characterized pigs as an optimal large-animal model, demonstrating its closer analogy to humans, resemblance to monkeys, and superiority over mice and other species, while identifying its perinatal stage as a transitional hub bridging early prenatal to postnatal molecular trajectories in humans. We revealed a pan-regional developmental inflection point (E94-E104) during the perinatal period, manifesting as order-of-magnitude changes in the expression of genes and proteins associated with synaptogenesis and gliogenesis. While further analysing developmental velocities across pig brain regions, we discovered regional heterogeneity exhibits a remarkably synchronized rise-and-fall pattern during the perinatal period. Additionally, brain disorder risk genes exhibited a perinatal transition to an adult-like organization in pigs, establishing this multi-omics atlas as a translational framework for decoding neurodevelopmental disorder pathogenesis.
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Registered trials
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