Evidence map›Paper›PMID 41922487›Full record

ReviewNPJ precision oncology2026

Mapping immunosuppressive terrain in high-grade serous ovarian cancer: tumor-intrinsic, stromal, and spatial drivers of therapy response.

Shouze Liu, Rulan Jiang, Zhongkang Li, Yanpeng Tian, Wenhua Liu, Yanfang Du, Shikai Liu, Bilan Li, Xianghua Huang

Abstract readReview
In one paragraph

Review in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shouze Liu *Department of Gynecology, The Second Hospital of Hebei Medical University, Hebei, PR China.
Rulan Jiang *Department of Reproductive Medicine, Cangzhou Hospital of Integrated TCM-WM Hebei, Hebei, PR China.
Zhongkang LiDepartment of Gynecology, The Second Hospital of Hebei Medical University, Hebei, PR China.
Yanpeng TianMedical School, Hunan University of Chinese Medicine, Changsha, PR China.
Wenhua LiuDepartment of Pain, Cangzhou Hospital of Integrated TCM-WM Hebei, Hebei, PR China.
Yanfang DuDepartment of Gynecology, The Second Hospital of Hebei Medical University, Hebei, PR China. yanfangdu0311@163.com.
Shikai LiuDepartment of Gynecology III, Cangzhou Central Hospital, Cangzhou, PR China. shikailiu0317@163.com.
Bilan LiShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, PR China. Libilan@51mch.com.
Xianghua HuangDepartment of Gynecology, The Second Hospital of Hebei Medical University, Hebei, PR China. xianghuahuang0311@163.com.

Funding

Natural Science Foundation of Hebei Province H2023206356
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) features a profoundly immunosuppressive tumor microenvironment (TME) that limits immunotherapy. Yet resistance is multilayered and spatially heterogeneous without an integrated framework. This review synthesizes recent advances that map multifaceted immune resistance in HGSOC across tumor-intrinsic, stromal, and spatial dimensions. Furthermore, we discuss potential translational strategies of remodeling the TME, with the goal of offering a context-aware roadmap for rational combination immunotherapy.

Identifiers

PMID41922487
PMCPMC13662190

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.