Evidence map›Paper›PMID 41922689›Full record

ArticleScientific reports2026

Longer leukocyte telomere length increases the odds of premature rupture of membranes: a cross-sectional study based on UK Biobank.

Chunting Xiao, Yan Su, Chuan Peng, Weike Li, Zhenyin Chen, Jing Long, Qianyan Shen, Yuquan Ran, Yingxiong Wang, Jinbo Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chunting Xiao *Department of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Yuzhong District, Chongqing, P. R. China.
Yan Su *Department of Clinical Laboratory, Chongqing Health Center for Women and Children/Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Chuan PengDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Yuzhong District, Chongqing, P. R. China.
Weike LiJoint International Research Laboratory of Reproduction & Development, School of public Health, Chongqing Medical University, No. 1 Medical College Rd, Yuzhong District, Chongqing, P. R. China.
Zhenyin ChenJoint International Research Laboratory of Reproduction & Development, School of public Health, Chongqing Medical University, No. 1 Medical College Rd, Yuzhong District, Chongqing, P. R. China.
Jing LongJoint International Research Laboratory of Reproduction & Development, School of public Health, Chongqing Medical University, No. 1 Medical College Rd, Yuzhong District, Chongqing, P. R. China.
Qianyan ShenDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Yuzhong District, Chongqing, P. R. China.
Yuquan RanDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Yuzhong District, Chongqing, P. R. China.
Yingxiong WangJoint International Research Laboratory of Reproduction & Development, School of public Health, Chongqing Medical University, No. 1 Medical College Rd, Yuzhong District, Chongqing, P. R. China.
Jinbo HuDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Yuzhong District, Chongqing, P. R. China. hujinbo@cqmu.edu.cn.
Rufei GaoDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Yuzhong District, Chongqing, P. R. China. gao_ru_fei@cqmu.edu.cn.

Funding

Outstanding Young Medical Talents Program of Chongqing No.YXQN202401Science and Technology Research Program of Chongqing Municipal Education Commission Grant No. KJQN202300418the National Natural Science Foundation of China No.82201858
6 · The paper itself

Abstract

This study aimed to explore the association between leukocyte telomere length (LTL) and premature rupture of membranes (PROM). This cross-sectional study included a total of 170,841 participants from the UK Biobank. Restricted cubic spline model (RCS) and logistic regression were used to evaluate the relationship between LTL and PROM. Subgroup analysis and interaction tests were conducted to test the stability of the results. RCS model showed a notable non-linear association between LTL and PROM. The logistic regression model further revealed that longer LTL was associated with an increased odds of developing PROM after fully adjusting for confounding factors. For every 1 unit increase in the original LTL, the odds of PROM significantly increases by 1.97 times (OR = 1.97, 95% CI:1.30-2.95). Compared with the Q1 of LTL, the PROM odds of Q3 and Q4 increased by 33% (OR = 1.33, 95% CI: 1.11-1.59) and 31% (OR = 1.31, 95% CI: 1.09-1.56). Finally, subgroup analysis found that age and education level play an important role in regulating the relationship between LTL and the odds of PROM. The research results indicate a non-linear relationship between LTL and PROM, and longer LTL is associated with higher PROM odds, which is influenced by age and education level.

Indexed as

LeukocytesPremature Rupture of Fetal MembranesTelomereTelomere HomeostasisAdultCross-Sectional StudiesFemaleHumansPregnancyUK BiobankUnited KingdomAssociationLeukocyte telomere lengthPremature rupture of membranes

Identifiers

PMID41922689
PMCPMC13181122

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.