The effects of β-caryophyllene on butyrate utilization and metabolism in Caco-2 cells.

H Scroggins, C Kent-Dennis, J May, D L Harmon, J L Klotz

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

H ScrogginsDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY, USA.

C Kent-DennisDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY, USA.

J MayDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY, USA.

D L HarmonDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY, USA.

J L KlotzUSDA-ARS Forage-Animal Production Research Unit, University of Kentucky Campus, Lexington, KY, 40546, USA. james.klotz@usda.gov.

Funding

USDA-ARS National Program 215 - Grass, Forage, and Rangeland Agroecosystems 5042-21000-005-000D

6 · The paper itself

Abstract

Β-caryophyllene (BCP) is a plant compound that may exert bioactive effects on intestinal epithelial cell (IEC) function, including metabolism of butyrate, which is important for regulating cellular functions. The goal of this study was to investigate the effects of BCP on butyrate utilization in IEC. Caco-2 cells were grown on hanging, semi-permeable inserts as a model for the intestinal barrier. Treatments, including vehicle control, 40 µM BCP, 2 mM butyrate, and BUT plus BCP were added to the apical side of the insert and incubated for 24 and 48 h. Transepithelial electrical resistance (TEER; ohms/cm

Indexed as

ButyratesPolycyclic Sesquiterpenes3-Hydroxybutyric AcidCaco-2 CellsEpithelial CellsHumansIntestinal Barrier FunctionIntestinal Mucosa3-Hydroxybutyric AcidButyratescaryophyllenePolycyclic Sesquiterpenes

Identifiers

PMID41922720

DOI10.1038/s41598-026-46790-6

PMCPMC13183966

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.