Evidence map›Paper›PMID 41922744›Full record

ArticleNature metabolism2026

ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas.

Marc Hennequart, Loic Mervant, Julie Stockis, Jack Coomes, Martha M Zarou, Louise Gerard, Virginie Tevel, Valérie Migeot, Steven E Pilley, Younghwan Lee and 12 more

Abstract read
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Good things come in twos.Nature metabolism · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Marc Hennequart *The Francis Crick Institute, London, UK. marc.hennequart@unamur.be.ORCID http://orcid.org/0000-0003-4360-6830
Loic Mervant *The Francis Crick Institute, London, UK.
Julie StockisUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-4911-6891
Jack CoomesThe Francis Crick Institute, London, UK.
Martha M ZarouThe Francis Crick Institute, London, UK.
Louise GerardNARILIS Institute, UNamur, Namur, Belgium.
Virginie TevelNARILIS Institute, UNamur, Namur, Belgium.
Valérie MigeotNARILIS Institute, UNamur, Namur, Belgium.
Steven E PilleyThe Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-9670-3314
Younghwan LeeThe Francis Crick Institute, London, UK.
Paul C DriscollThe Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-4124-6950
Nathalie M LegraveThe Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-1172-4955
Christiaan F LabuschagneHuman Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University Potchefstroom, Potchefstroom, South Africa.ORCID http://orcid.org/0000-0001-9474-5174
Fabio ZaniThe Francis Crick Institute, London, UK.
Alejandro Huerta UribeSchool of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.
Rute Machado De Morais FerreiraThe Francis Crick Institute, London, UK.
Eric C CheungThe Francis Crick Institute, London, UK.
Ilaria MalanchiThe Francis Crick Institute, London, UK.
James I MacRaeThe Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1464-8583
Oliver D K MaddocksSchool of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-5551-9091
Timotheus Y F HalimUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-9773-0023
Karen H VousdenThe Francis Crick Institute, London, UK. karen.vousden@crick.ac.uk.ORCID http://orcid.org/0000-0002-7365-1766

Funding

Cancer Research UK (CRUK) A24995Cancer Research UK (CRUK) C53309/A19702EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-2020-ADG PancObese 10102064EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-CoG-H2020725492Stichting Tegen Kanker (Belgian Foundation Against Cancer) F/2024/2752Wellcome Trust CC2073Wellcome Trust FC001112
6 · The paper itself

Abstract

Acinar-to-ductal metaplasia (ADM) contributes to pancreatic repair after injury

Indexed as

Acinar CellsPancreasPancreatic DuctsReactive Oxygen SpeciesAnimalsCarcinoma, Pancreatic DuctalHumansMetaplasiaMicePancreatic NeoplasmsReactive Oxygen Species

Identifiers

PMID41922744
PMCPMC13120998

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.