Evidence map›Paper›PMID 41922759›Full record

ArticleNature2026

Flexible ensheathment of axons enables myelination of complex CNS networks.

Cody L Call, Sarah A Neely, Jason J Early, Owen G James, Lida Zoupi, Anna C Williams, Yu Kang T Xu, Siddharthan Chandran, David A Lyons, Kelly R Monk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Actin disassembly triggers CNS myelin compaction and wrapping.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cody L CallThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA. cody.l.call@gmail.com.ORCID http://orcid.org/0000-0003-2254-4298
Sarah A NeelyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Jason J EarlyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4313-6445
Owen G JamesUK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9948-2190
Lida ZoupiCentre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7529-8492
Anna C WilliamsCentre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6329-382X
Yu Kang T XuThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Siddharthan ChandranUK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6827-1593
David A LyonsCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1166-4454
Kelly R MonkVollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-1803-3495
Dwight E BerglesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA. dbergles@jhmi.edu.ORCID http://orcid.org/0000-0002-7133-7378

Funding

Aging dependent transformation of oligodendrocyte precursor cellsR01AG072305 · NIA · JOHNS HOPKINS UNIVERSITY · PI BERGLES, DWIGHT E, GOFF, LOYAL ANDREW · 2021 to 2025
$2.0M
NIA NIH HHS R01 AG072305
6 · The paper itself

Abstract

Myelin sheaths made by oligodendrocytes in the central nervous system (CNS) are critical to circuit function and neural health. The distribution of these insulating sheaths varies substantially between brain regions

Indexed as

AxonsCentral Nervous SystemMyelin SheathAgingAnimalsCerebral CortexFemaleInterneuronsMaleMiceOligodendrogliaRanvier's NodesZebrafish

Identifiers

PMID41922759
PMCPMC13275323

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.