Evidence map›Paper›PMID 41922778›Full record

ArticleNature2026

AhR inhibition promotes axon regeneration via a stress-growth switch.

Dalia Halawani, Yiqun Wang, Jiaxi Li, Daniel Halperin, Haofei Ni, Molly Estill, Aarthi Ramakrishnan, Li Shen, Arthur Sefiani, Cédric G Geoffroy and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Dalia Halawani *Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4738-0656
Yiqun Wang *Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8223-2598
Jiaxi LiNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel HalperinNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1598-989X
Haofei NiNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6841-6262
Molly EstillNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aarthi RamakrishnanNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Li ShenNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5190-2851
Arthur SefianiDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, College Station, TX, USA.
Cédric G GeoffroyDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, College Station, TX, USA.
Roland H FriedelNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7513-3604
Hongyan ZouNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. hongyan.zou@mssm.edu.ORCID http://orcid.org/0000-0003-4216-5607

Funding

The Role of Core Circadian Regulator Bmal1 in Axonal Regeneration and Nerve RepairR01NS127442 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hongyan Jenny Zou · 2023 to 2026
$2.2M
Understanding the age-dependent mitochondrial function in astrocytes after spinal cord injury via bi-directional manipulation of activityR01NS128101 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MICHELLE A HOOK · 2022 to 2026
$1.9M
A novel adult neurons screening technology to repurpose FDA-approved drugs for spinal cord injuryR21NS131834 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI GEOFFROY, CEDRIC G · 2023 to 2023
$411k
NINDS NIH HHS R01 NS127442NINDS NIH HHS R01 NS128101NINDS NIH HHS R21 NS131834
6 · The paper itself

Abstract

Axon regeneration is limited in the mammalian central nervous system

Indexed as

AxonsBasic Helix-Loop-Helix ProteinsNerve RegenerationReceptors, Aryl HydrocarbonStress, PhysiologicalAnimalsDNA MethylationFemaleGanglia, SpinalHypoxia-Inducible Factor 1, alpha SubunitIntegrated Stress ResponseLigandsMicePeripheral Nerve InjuriesProteotoxic StressSignal TransductionAhr protein, mouseBasic Helix-Loop-Helix ProteinsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitLigandsReceptors, Aryl Hydrocarbon

Identifiers

PMID41922778
PMCPMC13216071

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.