Evidence map›Paper›PMID 41922848›Full record

ReviewSkeletal radiology2026

Insights into the complex relationship between pain and imaging-detected structural damage in knee osteoarthritis.

David Ferreira Branco, C Kent Kwoh, Theresa Patzer, Marco L Loggia, Ali Guermazi, Mohamed Jarraya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David Ferreira BrancoDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 6044, Boston, MA, USA.
C Kent KwohUniversity of Arizona Arthritis Center, College of Medicine, University of Arizona, Tucson, AZ, USA.
Theresa PatzerDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Germany.
Marco L LoggiaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 6044, Boston, MA, USA.
Ali GuermaziQuantitative Imaging Center, Department of Radiology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Mohamed JarrayaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 6044, Boston, MA, USA. mjarraya@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-8095-0174

Funding

Unraveling the discordance between structural damage and pain phenotypes in knee osteoarthritisK23AR084603 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$175k
NIAMS NIH HHS K23 AR084603NINDS NIH HHS R01NS094306U.S. Department of Defense W81XWH2211003
6 · The paper itself

Abstract

Knee osteoarthritis (OA) is a leading cause of chronic pain and disability, yet the relationship between imaging-detected structural damage and clinical pain remains still unclear. This persistent pain-structure discordance limits the effectiveness of current treatments and poses major challenges for clinical trial design and the development of disease-modifying OA drugs. Advances in imaging particularly MRI-based scoring systems have improved characterization of cartilage, bone, synovial, and meniscal pathology, but morphologic imaging alone cannot capture the neurobiological processes that shape the pain experience. This review summarizes pathophysiological changes and pain mechanism related to OA, followed by a review of pain assessment tools, a summary of our current understanding of the association between structural damage and pain experience in knee OA. Finally, we discuss emerging imaging tools, including positron emission tomography, which may help visualize inflammatory and neurobiological processes in both the knee joint and the brain.

Indexed as

ArthralgiaMagnetic Resonance ImagingOsteoarthritis, KneeHumansPain MeasurementPositron-Emission TomographyBone marrow lesionsCentral sensitizationKnee osteoarthritisMagnetic resonance imagingNeuroinflammationPain mechanismsSynovitis

Identifiers

PMID41922848

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.