ArticleGeroScience2026
The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
Abstract
The MetaboHealth score, a metabolomics-based biomarker trained on mortality, is associated with ageing-related phenotypes and morbidity, but its heritable component is still uncertain. Understanding genetic versus environmental contributions is essential for its utility as an intervention-responsive biomarker. Hence, the aim of this study was to estimate heritability of the MetaboHealth score in the large Swedish TwinGene cohort and evaluate interactions with modifiable lifestyle factors and health outcomes. We analysed 12,256 twins (55% female; mean age 64.8 years at blood draw) with Nightingale Health-based metabolomics data, followed until February 2024 (median follow-up time of 16.2 years). We subsequently estimated the heritability of the score using additive genetic (A), shared environmental (C), and unique environmental (E) (ACE) modelling via Cholesky decomposition in 1,370 monozygotic and 3,381 dizygotic twin pairs. Cox regression was used to assess mortality associations, with sensitivity analyses stratified by age, smoking, body mass index (BMI), and frailty. The MetaboHealth score was significantly associated with all-cause mortality (Hazard ratio (HR) = 1.91, 95% confidence interval (CI): 1.73-2.11; P = 1.32 × 10⁻
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Registered trials
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