ArticleChemistryOpen2026
Extraction and Optimization of Fucoidan From Sargassum muticum Using Acidic Eutectic Solvents and Evaluation of Their Effects on Fibroblast Cell Lines.
Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fucoidan, a sulfated polysaccharide extracted from the cell wall of macroalgae such as S. muticum, exhibits promising biological properties. This study investigated a green extraction using deep eutectic solvents (DESs), with an emphasis on process optimization and bioactive evaluation of fucoidan. The most efficient DES was lactic acid with glycerol (LacAc:Gly) at 60°C, with 4% water and a solid/liquid ratio of 0.1167, resulting in a yield of 6.6%, a sulfate content of 0.170 mg/mg, and a uronic acid content of 0.023 mg/mg. The chemical and structural composition of fucoidan were evaluated by colorimetric methods, FTIR, and NMR. Antioxidant activity was assessed by 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate (ABTS, 25.84%), 2-diphenyl-1-pricylhydrazyl (DPPH, 30.45%), and ferric reducing antioxidant power (FRAP, 690 µg/µg) assays. Cellular assays with L929 fibroblasts showed that concentrations of 50 and 75 µg/mL stimulated cell viability, with 179% colony formation and 449 invasive cells, suggesting positive effects on cell proliferation and migration. Therefore, the results indicate that fucoidan extracted with LacAc:Gly has high bioactive potential, demonstrating the viability of green eutectic solvents as a sustainable alternative for the utilization of bioactive compounds from brown algae.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.