Evidence map›Paper›PMID 41923640›Full record

ArticleCell2026

Sulfur partitioning from cysteine controls T cell proliferation and effector function.

Beth Kelly, Minsun Cha, Tatjana Gremelspacher, Jacob L Martin, Massimo Andreis, Isha Maloo, Gustavo E Carrizo, Mia Gidley, Michal A Stanczak, Petya Apostolova and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Beth KellyBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Minsun ChaBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tatjana GremelspacherBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacob L MartinBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Massimo AndreisBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Isha MalooBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gustavo E CarrizoBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mia GidleyBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michal A StanczakBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Petya ApostolovaBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedicine, University of Basel, Basel, Switzerland.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Eric H MaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Ryan D SheldonMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
David E SaninBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ananya MajumdarBiomolecular NMR Center, Johns Hopkins University, Baltimore, MD, USA.
Erika L PearceBloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: epearce6@jhmi.edu.

Funding

Phosphorylation of TSC2 (S1365) as a novel Regulator of mTORC1 Signaling in T CellsR01AI156274 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$496k
NIAID NIH HHS R01 AI156274
6 · The paper itself

Abstract

Delineating how acquired nutrients are partitioned into different intracellular pathways and how these various fates support distinct functions in T cells is limited. We show that CD8

Indexed as

CD8-Positive T-LymphocytesCysteineSulfurAnimalsCarcinoma, HepatocellularCell ProliferationGlutathioneHumansLiver NeoplasmsLymphocyte ActivationMiceMice, Inbred C57BLT-Cell ExhaustionCysteineGlutathioneSulfuranti-tumor immunityCD8+ T cellscysteineFe-S clustersglutathioneimmunometabolismiron uptakelipid peroxidationmitochondriaT cell exhaustion

Identifiers

PMID41923640
PMCPMC13108235

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.