Evaluating the exploratory classification performance of multimodal magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus: a prospective cohort study.

Haoyu Wang, MengFan Sun, Xiaojuan Yang, Sha Li, Shiling Zhou, Xiaoyao Lin, Qiyuan Zhu, Jun Liu

Abstract read

In one paragraph

Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

8 authors.

Haoyu WangDepartment of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.

MengFan SunDepartment of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.

Xiaojuan YangDepartment of Rheumatology and Immunology, Chongqing Emergency Medical Center, Chongqing, China.

Sha LiDepartment of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.

Shiling ZhouDepartment of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.

Xiaoyao LinDepartment of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.

Qiyuan ZhuDepartment of Medical Imaging, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Jun LiuDepartment of Medical Imaging, Chongqing Emergency Medical Center, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate the associations between magnetic resonance imaging (MRI) quantitative parameters with neuropsychiatric systemic lupus erythematosus (NPSLE), and to evaluate the exploratory classification performance for NPSLE. Methods: This study recruited 60 systemic lupus erythematosus (SLE) patients and 20 healthy controls (HC). Participants underwent multimodal MRI and clinical assessment. The diffusion tensor imaging analysis along the perivascular spaces value (DTI-ALPS) and Normalized Wall Index (NWI) were derived using Diffusion Tensor Imaging (DTI) and high-resolution vessel wall imaging (HR-VWI). MRI quantitative parameters were analyzed using Kruskal-Wallis test and Dunn's test pairwise comparisons. Partial correlation analysis was conducted on MRI parameters and clinical data. An exploratory multimodal classification model was developed. Results: The NPSLE group showed lower DTI-ALPS values and lumen area (LA), and higher NWI compared to the other groups ( Conclusion: NPSLE patients exhibited low DTI-ALPS values and high NWI compared to other groups. The exploratory model based on multimodal MRI quantitative parameters may provide imaging insights into cerebrovascular alterations and glymphatic dysfunction associated with NPSLE.

Indexed as

diffusion tensor imaging analysis along the perivascular spaceshigh-resolution vessel wall imagingmagnetic resonance imagingNormalized Wall Indexsystemic lupus erythematosus

Identifiers

PMID41924009

DOI10.3389/fnins.2026.1773928

PMCPMC13036176

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.