ArticleClinical interventions in aging2026
Correlation Analysis of the New Inflammatory Composite Index with the Degree of Coronary Artery Lesions in Elderly Patients.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Type 2 diabetes mellitus and incident carotid atherosclerosis: a retrospective cohort study on composite indices.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Systemic inflammation plays a key role in the development and progression of coronary artery disease (CAD). However, the clinical relevance of hematologic inflammatory indices in elderly patients has not been fully clarified. Objective: To investigate the association of five hematologic inflammatory indices-neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI)-with the presence and severity of CAD in an elderly population. Methods: This retrospective single-center study included 582 consecutive patients aged ≥60 years who underwent coronary angiography between 2021 and 2023. Based on the extent of coronary artery involvement, patients were categorized into four groups: normal (n = 131), single-vessel disease (n = 133), two-vessel disease (n = 136), and three-vessel disease (n = 182). Inflammatory indices were calculated from routine blood counts. Group differences were assessed using the Kruskal-Wallis test. Multivariable logistic regression analysis was performed after adjustment for age, sex, body mass index, hypertension, and diabetes. Discriminatory performance was evaluated using receiver operating characteristic (ROC) curve analysis with comparisons conducted by the DeLong test. Results: All five inflammatory indices were significantly associated with increasing angiographic severity of CAD (all Conclusion: This study demonstrates that SIRI and SII are valuable inflammatory biomarkers for evaluating the severity of coronary artery disease in elderly patients, highlighting the role of systemic inflammation in the progression of age-related atherosclerosis. As the first systematic comparison of five hematologic composite indices in a geriatric cohort, our findings suggest that SII and SIRI-both cost-effective and readily available parameters-are closely associated with CAD severity, though prospective studies are needed to establish their clinical value.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.