Evidence map›Paper›PMID 41924222›Full record

ReviewInternational journal of preventive medicine2026

Melatonin Supplementation in Iranian Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Exploring Oxidative Stress and Inflammation.

Seyed Sobhan Bahreiny, Reza Mohammadpour Fard, Akram Ahangarpour, Razieh Kazemzadeh, Mohammad Rashno, Mohammad Reza Dabbagh, Maryam Radan, Khojasteh Hoseinynejad

Abstract readReview
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In one paragraph

Review in International journal of preventive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seyed Sobhan BahreinyDepartment of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Reza Mohammadpour FardStudent Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Akram AhangarpourDepartment of Physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Razieh KazemzadehStudent Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mohammad RashnoCellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mohammad Reza DabbaghDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Maryam RadanDepartment of Physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Khojasteh HoseinynejadDepartment of Physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetes mellitus is a global health challenge characterized by oxidative stress (OS) and persistent inflammation, which contribute to the progression of complications. Melatonin, a multifaceted hormone known for its potent antioxidant and anti-inflammatory properties, has emerged as a potential therapeutic intervention in diabetes. This systematic review and meta-analysis aimed to evaluate the effects of melatonin supplementation on crucial biomarkers of OS (malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione (GSH)) and inflammation (C-reactive protein (CRP)) in Iranian diabetic patients. Methods: A thorough literature search was conducted until August 2023 in MEDLINE (PubMed), Embase, Web of Science, Cochrane Central, Magiran, and Scopus databases using keywords corresponding to MeSH, such as "diabetes," "melatonin," "oxidative stress," "randomized clinical trial," and "Iranians." The study focused on eight randomized controlled trials conducted on diabetic patients in Iran. The data were analyzed using the random-effects model, and the summary effect size was determined using the standardized mean difference (SMD). Results: Our research indicates that melatonin supplementation led to significant reductions in CRP levels (SMD) = -1.74; 95% confidence interval (CI): -2.79, -0.69; Conclusions: Melatonin supplementation is a promising complementary strategy to attenuate OS and inflammation in diabetic patients.

Indexed as

C-reactive proteindiabetesglutathionemalondialdehydemelatonintotal antioxidant capacity

Identifiers

PMID41924222
PMCPMC13038273

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.