ArticleTherapeutic advances in gastroenterology2026
Comparative study on the application of fully covered self-expanding metal stents in benign and malignant strictures of the distal bile duct.
Article in Therapeutic advances in gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Endoscopic placement of fully covered self-expanding metal stents (FCSEMS) is a treatment for distal biliary strictures (DBS). However, there remains a notable gap in the research regarding the efficacy and safety of FCSEMS in benign distal biliary stricture (BDBS) and malignant distal biliary stricture (MDBS). Objective: To compare the short-term efficacy and long-term safety of FCSEMS in benign versus malignant DBS. Design: A retrospective, single-center cohort study. Methods: We conducted a retrospective analysis of 123 patients with DBS who underwent FCSEMS placement via endoscopic retrograde cholangiopancreatography (ERCP) at Shanghai East Hospital Affiliated to Tongji University from January 2019 to December 2024. Patients were stratified into BDBS ( Results: Median follow-up durations were comparable between BDBS (6 (4,9) months) and MDBS (7 (4,12) months) groups ( Conclusion: FCSEMS effectively alleviates strictures in both benign and malignant DBS, with comparable short-term efficacy. Notably, BDBS patients had a higher risk of early PEP, whereas MDBS patients were more prone to late biliary infections. Long-term stricture resolution was not analyzed due to divergent disease trajectories (e.g., limited survival in MDBS).
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