Evidence map›Paper›PMID 41924449›Full record

ReviewInternational journal of nanomedicine2026

Recent Advances in Nanocarrier-Based Drug Delivery Systems for Lung Cancer.

Zhengjun Li, Chang Liu, Zexi Di, Guofeng Zhang, Sibo You, Siwei Chao, Yi Ren

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhengjun Li *Department of Thoracic Surgery, Shenyang Chest Hospital, Shenyang, 110044, People's Republic of China.
Chang Liu *Department of Thoracic Surgery, Shenyang Chest Hospital, Shenyang, 110044, People's Republic of China.ORCID 0000-0002-5930-3255
Zexi Di *Central Hospital Affiliated to Shenyang Medical College, Shenyang Medical College, Shenyang, 110024, People's Republic of China.
Guofeng ZhangDepartment of Thoracic Surgery, Shenyang Chest Hospital, Shenyang, 110044, People's Republic of China.
Sibo YouDepartment of Thoracic Surgery, Shenyang Chest Hospital, Shenyang, 110044, People's Republic of China.
Siwei ChaoShenyang Medical College, Shenyang, 110034, People's Republic of China.ORCID 0009-0007-3871-5203
Yi RenDepartment of Thoracic Surgery, Shenyang Chest Hospital, Shenyang, 110044, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer (LC) remains the leading cause of cancer-related deaths globally. Conventional therapeutic strategies, including surgery, radiotherapy, and chemotherapy, are often hampered by limitations such as poor tumor selectivity, low bioavailability, and severe systemic toxicity, which compromise treatment efficacy. Nanocarriers are colloidal formulations characterized by abundant porosity and unique physicochemical properties, such as tunable size, high specific surface area, and stimuli-responsiveness. Nanocarrier-based drug delivery systems (NDDSs) have emerged as a promising solution to enable targeted delivery, controlled drug release, and theranostics. This review discusses the advantages, limitations, and clinical translation of three major classes of nanodelivery systems for LC therapy: organic, inorganic, and inorganic-organic hybrid nanosystems. Organic systems are characterized by high biocompatibility and versatile drug-loading capacity, whereas inorganic counterparts provide distinctive optical or magnetic functionalities that enable imaging and synergistic therapy. Hybrid designs integrate both material classes to improve stability and therapeutic performance. Future research is expected to focus on optimizing inhalation strategies for deep lung deposition, developing multi-targeted biomimetic carriers, advancing theranostic platforms, and employing computational tools to accelerate nanocarrier design and clinical translation. This review aims to offer critical perspectives on the development and clinical implementation of nanomedicines for LC.

Indexed as

Antineoplastic AgentsDrug CarriersDrug Delivery SystemsLung NeoplasmsNanoparticle Drug Delivery SystemAnimalsHumansNanomedicineTheranostic NanomedicineAntineoplastic AgentsDrug CarriersNanoparticle Drug Delivery Systemclinical translationinorganic nano-delivery systemsinorganic-organic hybrid nano-delivery systemslung cancerNDDSsorganic nano-delivery systemstargeted therapytheranostics

Identifiers

PMID41924449
PMCPMC13037513

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.