ArticleJournal of magnetic resonance imaging : JMRI2026
Chronic Liver Disease: Assessing Inflammation and Fibrosis Using Three-Dimensional MR Elastography With Same-Day Biopsy in a Prospective Cohort.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThree-dimensional (3D) MR elastography (MRE) derives viscoelastic parameters that may reflect inflammation, but their frequency dependence and the influence of steatosis on inflammation grading and fibrosis staging remain unclear. PURPOSE: To investigate 3D multifrequency MRE for assessing hepatic inflammation, fibrosis stage across frequencies, and the influence of steatosis. STUDY TYPE: Prospective. POPULATION: Sixty-four (40 men, median age: 58 years) participants with chronic liver disease (CLD); 21 (8 men, median age: 28 years) healthy volunteers. FIELD STRENGTH/SEQUENCE: 3-T; gradient-echo sequence with mechanical vibrations at low (16.7 and 18 Hz), medium (33.4 and 36 Hz), and high (50.1 and 54 Hz) frequencies. ASSESSMENT: In CLD participants, MRE-derived viscoelastic parameters, shear stiffness, storage modulus, loss modulus, and damping ratio were compared with histologically assessed fibrosis, inflammation, and steatosis. MRE test-retest repeatability over 10 min was evaluated in healthy volunteers. STATISTICAL TESTS: Wilcoxon rank sum test, Spearman's correlation, multivariable regression analysis, and area under the receiver operating curve (AUROC). A p value of < 0.05 was considered statistically significant.
resultsInflammation was significantly independently associated with damping ratio at medium frequency, which showed moderate performance for grading inflammation (AUROC = 0.76-0.83, sensitivity = 0.83-0.84, specificity = 0.70-0.79). Fibrosis staging using shear stiffness and moduli showed high diagnostic performance (AUROC = 0.82-0.95), with comparable accuracy between medium and high frequencies (p = 0.327-0.896). Steatosis was not significantly correlated with MRE overall (p = 0.212-0.459), but was significantly associated with 19% higher stiffness and 20% higher loss modulus at medium frequency in CLD participants without fibrosis or inflammation. DATA
conclusionMedium frequency 3D MRE demonstrated an independent association with inflammation while preserving accurate fibrosis assessment. Steatosis seemed not to confound MRE-based evaluation. LEVEL OF EVIDENCE: 1: TECHNICAL EFFICACY: Stage 2.
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