Evidence map›Paper›PMID 41925999›Full record

ReviewFood science of animal resources2026

Health benefits and value addition of bovine colostrum (BC): a comprehensive review of its nutritional and functional potential.

Sawera Riaz, Ali Imran, Musarrat Rasheed, Aleeza Amjad, Amar Shankar, Gauri Chauhan, Zunaira Basharat, Fakhar Islam, Usman Naeem, Catherine Tamale Ndagire

Abstract readReview
In one paragraph

Review in Food science of animal resources, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sawera RiazGovernment College University, Faisalabad, Pakistan.
Ali ImranGovernment College University, Faisalabad, Pakistan. aliimran.ft@gmail.com.
Musarrat RasheedNUR International University, Lahore, Pakistan.
Aleeza AmjadGovernment College University, Faisalabad, Pakistan.
Amar ShankarSharda School of Pharmacy, Sharda University, Greater Noida, UP, India.
Gauri ChauhanFaculty of Pharmacy, Gokul Global University, Sidhpur, Gujrat, India.
Zunaira BasharatJiangsu University, Zhenjiang, China.
Fakhar IslamGovernment College University, Faisalabad, Pakistan. fakhar.ft440@gmail.com.
Usman NaeemUniversity of Lahore, Lahore, Pakistan.
Catherine Tamale NdagireMountains of the Moon University, Fort Portal, Uganda. catherinendagire@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present review tries to explore composition, processing technologies, bioactive components, and clinical applications of BC, laying especial emphasis on their nutritional and therapeutic potentials. BC is highly bioactive secretion enriched with macronutrients and a wide spectrum of bio-functional molecules such as immunoglobulin (IgG, IgA, and IgM), lactoferrin, growth factors (IGF-1, TGF-β), proline-rich polypeptides, cytokines, and bioactive peptides. These mutually act in immune modulation, gastrointestinal integrity, epithelial repair, and antimicrobial defense. Advanced processing technologies, such as freeze-drying, spray-drying, and low-temperature vacuum drying, are important for maintaining structural stability and ensuring the biological activity of heat-sensitive immunoglobulins, peptides, and probiotics that assure extended shelf life and industrial scalability. Recent knowledge in omics-based proteomics and transcriptomic has unraveled new components like microRNAs, osteopontin, milk fat globule membrane proteins, and lactoperoxidase, which have come to bear upon a critical role in the regulation of immune response, epithelial protection, and anti-inflammatory signaling. These molecular understandings of BC bring its functionality as an active therapeutic ingredient for clinical nutrition, sports recovery, and management of conditions where immune fitness is compromised. Clinical evidence has established the effectiveness of BC in soothing irritable bowel syndrome, ulcerative colitis, infectious diarrhea, metabolic dysfunction, regeneration of tissues, wound healing, and anti-aging properties. BC applications continue into functional foods, nutraceuticals, and pharmaceutical formulations, and currently, new and innovative encapsulation and delivery systems are being developed, which enhance its bioavailability and targeting activities. In this context, bovine colostrum is emerging as an attractive bio-functional ingredient for an expanding application in human health and with commercial viability, considering present consumers' trends toward natural products with immune-enhancing and regenerative features.

Indexed as

Bioactive peptidesBovine colostrumFreeze-dryingFunctional foodsHealth effectsImmune modulationImmunoglobulinsProteomics

Identifiers

PMID41925999
PMCPMC13047012

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.