Evidence mapPaperPMID 41926051Full record

ReviewPaediatric drugs2026

GLP-1 Receptor Agonist Use Across Preconception, Pregnancy, and the Postpartum Periods.

Florence Porterfield, Serena Michelle Ogunwole, Jacqueline Maya, Fatima Cody Stanford

Abstract readReview
PubMed Publisher
In one paragraph

Review in Paediatric drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Florence PorterfieldDepartment of Medicine, Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 430, Boston, MA, 02114, USA.
Serena Michelle OgunwoleDepartment of Medicine, Johns Hopkins Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9479-7695
Jacqueline MayaHarvard Medical School, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9836-3448
Fatima Cody StanfordDepartment of Medicine, Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 430, Boston, MA, 02114, USA. fstanford@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-4616-533X

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · MASSACHUSETTS GENERAL HOSPITAL · 1994 to 2025
$6.0M
Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)K12DK133995 · STANFORD UNIVERSITY · 2025 to 2025
$3.7M
Creating Opportunities for Unparalleled Researchers to Achieve Growth and Excellence (COURAGE)U24DK132733 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$811k
Accelerating Research Advancement for Early Career Investigators in AcademiaUE5DK137285 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$160k
American Diabetes Association 9-24-JDFWH-01American Heart Association-Bristol Myers Squibb Foundation Winn Diversity in Clinical Trials Clinical Investigator Leadership AwardMassachusetts General Hospital MGH Physician-Scientist Development AwardNIDDK NIH HHS K12DK133995NIDDK NIH HHS P30 DK040561NIDDK NIH HHS U24 DK132733NIDDK NIH HHS UE5 DK137285
6 · The paper itself

Abstract

Obesity in reproductive-age women is associated with increased risk of cardiometabolic disease, infertility, and pregnancy-related complications affecting both the mother and fetus. Recently, the introduction of highly effective glucagon-like peptide-1 (GLP-1) receptor agonists has led to increased utilization of obesity medications in this population. While these agents are not recommended during pregnancy, their use in the preconception, periconception, and postpartum periods is increasing. Yet, data on their safety and clinical utility during these reproductive windows remain limited. This review summarizes the current literature on the risks and benefits of GLP-1 receptor agonist use for both the mother and fetus, highlighting the need for ongoing high-quality research in this population. This review highlights key clinical considerations across reproductive stages, emphasizes the primacy of human exposure data where available, and identifies critical evidence gaps requiring future prospective study.

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsObesityPregnancy ComplicationsAnimalsFemaleHumansPostpartum PeriodPregnancyGlucagon-Like Peptide-1 Receptor Agonists

Identifiers

PMID41926051

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.