ArticleNPJ science of food2026
Human milk and infant formula influence lactobacilli metabolism in a species-specific manner.
Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The maternal gut-fetal brain axis: role of maternal microbial metabolome in early neurodevelopment.Frontiers in nutrition · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
The neonatal gut is colonized by commensal bacteria, including lactobacilli, that play a critical role in promoting host health. While lactobacilli are known for producing bioactive metabolites, species-specific responses to neonatal diets remain unclear. We hypothesized that human milk and infant formula would differentially influence lactobacilli metabolite production. Six species (Lactobacillus acidophilus, Levilactobacillus brevis, Lactobacillus johnsonii, Lacticaseibacillus paracasei, Limosilactobacillus reuteri, Lacticaseibacillus rhamnosus) were cultured in defined media with human milk, formula, or water, and supernatants were analyzed via untargeted LC-MS/MS metabolomics. Principal coordinates analyses showed distinct metabolomic profiles among lactobacilli species and across dietary treatments. Human milk enhanced the production of several metabolites, including hydroxyphenyllactic acid, tyrosine, indoles, vaccenic acid, and di-peptides. Interestingly, several unique metabolites were upregulated in the presence of infant formula, including isonicotinic acid. These results highlight the differential effects of human milk and infant formula on the metabolomic profiles of lactobacilli species, emphasizing significant species-specific variation and pronounced production of potentially beneficial compounds in response to human milk. This work underscores the importance of understanding diet-microbe interactions to optimize neonatal gut health.
Identifiers
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Registered trials
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