Evidence map›Paper›PMID 41927601›Full record

ArticleScientific data2026

A Labrador PeptideAtlas and DIA spectral assay library - resources for proteomics research in dogs.

Ulrike Kusebauch, Zhi Sun, Mukul K Midha, Charu Kapil, Michal Maes, David H Baxter, Seamus R Morrone, Panga J Reddy, Ciaran O'Flynn, Phillip Watson and 3 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. AData in brief · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ulrike KusebauchInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA. ukusebauch@systemsbiology.org.ORCID http://orcid.org/0000-0001-6162-7577
Zhi SunInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0003-3324-6851
Mukul K MidhaInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.
Charu KapilInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.
Michal MaesInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.
David H BaxterInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.
Seamus R MorroneInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.
Panga J ReddyInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.
Ciaran O'FlynnWaltham Petcare Science Institute, Waltham-on-the-Wolds, Leicestershire, LE14 4RT, UK.
Phillip WatsonWaltham Petcare Science Institute, Waltham-on-the-Wolds, Leicestershire, LE14 4RT, UK.ORCID http://orcid.org/0000-0002-4381-9388
Eric W DeutschInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-8732-0928
David AllawayWaltham Petcare Science Institute, Waltham-on-the-Wolds, Leicestershire, LE14 4RT, UK.ORCID http://orcid.org/0000-0003-4602-8933
Robert L MoritzInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA, 98109, USA. rmoritz@systemsbiology.org.ORCID http://orcid.org/0000-0002-3216-9447

Funding

Acquisition of Fusion Lumos Orbitrap mass spectrometerS10OD026936 · OD · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2019 to 2019
$600k
National Science Foundation (NSF) 1920268National Science Foundation (NSF) DBI-2324882U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) S10OD026936
6 · The paper itself

Abstract

The domestic dog, Canis lupus familiaris, plays a vital role as companion or service animal, and the well-being and healthy aging of dogs is gaining importance. Proteins are key actors in cells, tissues and body fluids, and the ability to measure their composition and abundance is crucial to understand biological processes. We report a mass spectrometry-based proteomics approach analyzing canine tissues, plasma and urine obtained from Labrador retrievers to develop two comprehensive resources to advance the study of the dog proteome. Firstly, we developed a Labrador PeptideAtlas covering 49% of the predicted UniProtKB proteome and secondly, a Labrador spectral assay library for targeted applications by data-independent acquisition that enables the identification and quantification of 11,792 proteins (11,564 protein groups) of the dog proteome (56%). We demonstrate the performance of the library with gradients of different length and quantify 10,140 proteins in tissues and 385 proteins in plasma.

Indexed as

ProteomeProteomicsAnimalsDogsMass SpectrometryProteome

Identifiers

PMID41927601
PMCPMC13046798

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.