Evidence map›Paper›PMID 41927671›Full record

ArticleScientific reports2026

A low-magnitude high-frequency vibrator utilizing a specific amplitude and frequency for bone remodeling conducive to orthodontic tooth movement.

Zhouqiang Wu, Qingsong Jiang, Yiyin Chen, Hu Long, Wenli Lai, Xuepeng Chen

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Zhouqiang WuDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, Hangzhou, 310006, People's Republic Of China.
Qingsong JiangState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, People's Republic Of China.
Yiyin ChenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, People's Republic Of China.
Hu LongState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, People's Republic Of China.
Wenli LaiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, People's Republic Of China. wenlilai@scu.edu.cn.
Xuepeng ChenDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, Hangzhou, 310006, People's Republic Of China. cxp1979@zju.edu.cn.

Funding

National Natural Science Foundation of China 82071147
6 · The paper itself

Abstract

Finding a method to accelerate tooth movement is crucial to avoid the harmful effects of long-term orthodontic treatment. Low-magnitude high-frequency (LMHF) vibration may be an effective method. This study examined the effect of varying LMHF vibrator frequencies on alveolar bone during orthodontic tooth movement (OTM). The OTM model was established, and an LMHF vibrator was used to apply mechanical stress (0, 25, 50, 75, and 100 Hz). After Yoda1/GsMTx4TFA was periodically injected into the periodontal ligament, LMHF vibration was applied at an appropriate frequency. Micro-CT, HE staining, and IHC (Piezo1) were used to investigate the mechanism by which mechanical stress regulates alveolar bone metabolism via the Piezo1 receptor. LMHF vibration at different frequencies significantly increased the bone volume fraction (BV/TV), bone mineral density (BMD), and trabecular thickness (Tb.Th) of the alveolar bone in the 75-Hz group. The expression of the Piezo1 receptor also increased. The expression of the Piezo1 receptor increased in the 75-Hz + Yoda1 group, and the BMD, BV/TV, and Tb.Th increased, while the expression of the Piezo1 receptor decreased in the 75-Hz + GsMTx4TFA group as the BV/TV, BMD, and Tb.Th of the alveolar bone decreased. An appropriate LMHF (75 Hz) can promote the expression of Piezo1 receptors in the periodontal ligament and promote the osteogenesis of alveolar bone, accelerating orthodontic tooth movement.

Indexed as

Bone RemodelingTooth Movement TechniquesVibrationAlveolar ProcessAnimalsBone DensityIon ChannelsMicePeriodontal LigamentStress, MechanicalX-Ray MicrotomographyIon ChannelsAccelerationLow-magnitude high-frequencyMechanical stressOrthodontic tooth movementPiezo1

Identifiers

PMID41927671
PMCPMC13194842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.