ArticleScientific reports2026
Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infection in Cthrc1-positive pulmonary fibroblasts derived from the Nile grass rat.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Disturbances in sleep and circadian rhythms are observed as sequelae of COVID-19 syndrome. However, the pathogenetic mechanisms remain largely unknown. Here, we established a fibroblast cell line (GrLBmal1-luc) from the lungs of diurnal Nile grass rats stably expressing the Bmal1-luciferase reporter gene to investigate peripheral clock regulation. First, endogenous receptor expression was screened with quantitative RT-PCR, immunohistochemistry, Ca2+ imaging, and Bmal1-luciferase reporter in GrLBmal1-luc cells. Through these, the present study discovered phase-shifting effects of adrenaline via β2-adrenoceptor. Interestingly, GrLBmal1-luc cells expressed collagen triple helix repeat containing-1 (Cthrc1) and exhibited a morphology typical of fibroblasts that accumulate in the fibrotic lungs of severe COVID-19 patients. Therefore, human angiotensin-converting enzyme-2 (ACE2) receptors were overexpressed in GrLBmal1-luc cells, and the effects of SARS-CoV-2 (Omicron, XBB.1) infection were analyzed. Following SARS-CoV-2 infection, Bmal1 transcriptions were significantly reduced, while IL-6 and Ciart transcriptions were upregulated. Rev-erbα and Per1 transcriptions were not substantially impacted. The flattened Bmal1-luciferase rhythms gradually recovered 4 days after infection, and adrenaline stimulation amplified and recovered the rhythms faster compared with unstimulated controls. These results provide insight into the molecular mechanisms underlying circadian rhythm disturbances during SARS-CoV-2 infection, and they suggest that adrenergic agents may have therapeutic potential in COVID-19 patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.