Evidence map›Paper›PMID 41928090›Full record

ReviewCellular & molecular biology letters2026

Palmitoylation-dependent regulation of innate and adaptive immunity: molecular insights and translational opportunities.

Binhui Zhou, Bowen Zhang, Yingcheng Qi, Sainan Li, Tingting Liu, Tong Li, Ying Wang, Haifeng Wang, Jiaqi Lu, Fei Cao and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular & molecular biology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Binhui Zhou *The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China. zhoubinhui@gris.org.cn.
Bowen Zhang *Laboratory of Genetic Regulators in the Immune System, School of Medical Technology, Henan Medical University, Xinxiang, Henan, China.
Yingcheng Qi *Laboratory of Genetic Regulators in the Immune System, School of Medical Technology, Henan Medical University, Xinxiang, Henan, China.
Sainan Li *Institute of Psychiatry and Neuroscience of Henan Medical University, Xinxiang, Henan, China.
Tingting Liu *Laboratory of Genetic Regulators in the Immune System, School of Medical Technology, Henan Medical University, Xinxiang, Henan, China.
Tong Li *Laboratory of Genetic Regulators in the Immune System, School of Medical Technology, Henan Medical University, Xinxiang, Henan, China.
Ying Wang *The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Haifeng WangThe First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Jiaqi LuThe First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Fei CaoThe First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Xiaohong KangThe First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Eryan KongThe First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Yinming LiangLaboratory of Genetic Regulators in the Immune System, School of Medical Technology, Henan Medical University, Xinxiang, Henan, China. yinming.liang@gris.org.cn.

Funding

Natural Science Foundation of Henan Province 252300420216the Natural Science Foundation of Henan Province 252300421679the Research Start-up Funding of Henan Medical University 505483
6 · The paper itself

Abstract

Immune cells orchestrate organismal defense through pathogen surveillance, tissue homeostasis, and immune tolerance, with innate and adaptive subsets coordinating context-specific responses. The dynamic lipid modification, S-palmitoylation (often referred to simply as palmitoylation), regulates membrane trafficking, signal transduction, and protein–protein interactions by spatiotemporally controlling the localization, stability, and activity of immune mediators. Dysregulation of this process in immune cells contributes to pathologies including immunosuppression, chronic inflammation, and autoimmunity. This review synthesizes current knowledge on how palmitoylation governs immune cell development, subset-specific functions, and immune-mediated pathologies—encompassing metabolic disorders, infectious diseases, autoimmune disorders, and cancer. We further explore the diagnostic and therapeutic potential of targeting palmitoyltransferases, depalmitoylases, and palmitoylation-dependent immune checkpoints to restore immune equilibrium. By integrating mechanistic insights into palmitoylation-dependent immune regulation with translational applications, this work underscores the potential of palmitoylation-centric biomarkers and therapies to transform immunological diagnostics and treatment.

Indexed as

Adaptive ImmunityImmunity, InnateLipoylationAnimalsHumansSignal TransductionDiagnostic biomarkersImmune cellsImmune-mediated diseasesProtein palmitoylationTherapeutic targeting

Identifiers

PMID41928090
PMCPMC13270668

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.