Evidence map›Paper›PMID 41928245›Full record

ArticleJournal of nanobiotechnology2026

Photoactivated probiotic micro-reactor synchronizes STING/TLRs agonists to spatiotemporally synergize antitumor immunotherapy.

Yuzhi Qiu, Yunting Liu, Sihan Chen, Yidi Liu, Xi Yu, Xiangliang Yang, Yan Zhang, Yanhong Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuzhi QiuNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China.
Yunting LiuNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China.
Sihan ChenNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China.
Yidi LiuNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China.
Xi YuNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China.
Xiangliang YangNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China. nanomedicine@mail.hust.edu.cn.
Yan ZhangNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China. yan_zhang@hust.edu.cn.
Yanhong ZhuNational Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China. yhzhu@hust.edu.cn.

Funding

National Key Research and Development Program of China 2021YFA1201200National Natural Science Foundation of China 82172083
6 · The paper itself

Abstract

Reprogramming tumor-associated macrophages (TAMs) from the pro-tumoral M2-like state to the immunostimulatory M1-like phenotype has emerged as a promising strategy for tumor therapy. However, most M2-like TAMs are preferentially located in hypoxic regions of the tumor, which are poorly accessible to many advanced drug delivery systems, posing a significant challenge to effective TAM reprogramming. Here, leveraging the tropism of facultative anaerobic bacteria to localize and propagate in the hypoxic tumor, an optogenetically engineered Escherichia coli Nissle 1917 strain conjugated with murine STING agonist (EcN

Indexed as

NeoplasmsProbioticsSTING ProteinToll-Like ReceptorsAnimalsCell LineDrug SynergismFemaleImmunotherapyMiceMice, Inbred BALB CNanoparticlesPhotosensitizing AgentsTumor-Associated MacrophagesPhotosensitizing AgentsSting1 protein, mouseSTING ProteinToll-Like ReceptorsCancer immunotherapyEngineered bacteriaOptogeneticsPhotolabile STING prodrug

Identifiers

PMID41928245
PMCPMC13169788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.