ArticleChinese medicine2026
Sichuan pepper, Zanthoxylum bungeanum Maxim., suppresses human coronavirus OC43 infection by inhibiting viral entry and impairing autolysosome accumulation.
Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe dried pericarp of Zanthoxylum bungeanum Maxim. (Rutaceae), widely recognized as Sichuan pepper (Hua Jiao), is a prominent herb within the Traditional Chinese Medicine (TCM), boasting a long and well-documented history of ethnopharmacological application. Its traditional uses primarily involve the internal management of gastrointestinal ailments, such as stomachaches, alongside promoting systemic blood circulation. Building on this traditional foundation, modern pharmacological studies have confirmed and extended its therapeutic profile, revealing potent anti-inflammatory and antitumor biological activities. We examined the anticoronaviral effects and the mechanism of action of the 30% ethanol extract of Z. bungeanum against human coronavirus (HCoV)-OC43 infection.
methodsAntiviral activity was measured using the virus-induced cytopathic effect (CPE) reduction assay, qRT-PCR was performed to calculate viral RNA copy numbers, and western blotting and immunofluorescence staining were performed to detect viral proteins. To evaluate the mode of action of Z. bungeanum, time-of-addition, attachment, penetration, and virucidal assays were performed. The effect of the extract on virus-induced autophagic flux was examined by measuring LC3 protein expression via western blotting, and autophagy, lysosomes, and lysosomal degradation were assessed using CYTO-ID® Green, LysoTracker™ Deep Red, and DQ™ Red BSA, respectively. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry was used to identify the active components in the extract.
resultsZ. bungeanum extract protected against HCoV-OC43-induced CPEs with IC
conclusionsThis study suggested the potential of Z. bungeanum as a novel anticoronaviral agent.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.