Evidence map›Paper›PMID 41928293›Full record

ArticleJournal of animal science and biotechnology2026

Comparative liver proteome analysis of feedlot steer calves reveals growth trait-specific pathways influenced by calving season.

Chris Johnson, Amit Singh, Zahid Hasan, Kamrul Islam, Zhibo Yang, Mindy King, Andrew Foote, David Lalman, Nagib Ahsan, Paul Beck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chris Johnson *Animal & Food Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.
Amit Singh *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA.
Zahid HasanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA.
Kamrul IslamDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA.
Zhibo YangDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Mindy KingDepartment of Animal Science and Industry, Kansas State University, Manhattan, KS, 66506, USA.
Andrew FooteAnimal & Food Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.
David LalmanAnimal & Food Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.
Nagib AhsanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA. nahsan@ou.edu.
Paul BeckAnimal & Food Sciences, Oklahoma State University, Stillwater, OK, 74078, USA. paul.beck@okstate.edu.

Funding

U.S. Department of Agriculture, National Institute of Food and Agriculture 2022-67016-36201
6 · The paper itself

Abstract

backgroundThe bovine liver is a key organ governing nutrient metabolism, immune regulation, and growth. However, the effects of birth season and growth potential on hepatic protein expression remain poorly understood.

resultsThis study investigated the liver proteome of steer calves born during the spring and fall 2023 calving seasons (n = 5-6 steer/growth trait/season). Using a comparative label-free quantitative proteomics approach, 2,133 proteins were identified and quantified following feedlot entry. Principal component and hierarchical clustering analyses revealed distinct segregation of protein expression profiles according to both birth season (spring vs. fall) and growth trait (high vs. moderate), with calving season exerting the stronger overall influence. Bioinformatic and pathway enrichment analyses identified significant growth- and season-independent proteins. Growth-associated proteins were primarily involved in immune signaling, including antigen processing and presentation, as well as glutathione-CYP detoxification pathways. In contrast, season-independent proteins were enriched in pathways related to circadian rhythm, hormonal regulation, and muscle contraction.

conclusionThese results demonstrate that both growth trajectory and season of birth independently modulate the bovine liver proteome, with stronger seasonal effects, providing novel insight into the metabolic and immune mechanisms underlying variation in calf growth performance.

Indexed as

Birth seasonBovine liverFeedlot performanceGrowth potentialProteomics

Identifiers

PMID41928293
PMCPMC13047832

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.