Evidence map›Paper›PMID 41928957›Full record

ArticlebioRxiv : the preprint server for biology2026

Single-Molecule Methods to Investigate Mechanisms of Transcription by RNA Polymerase of

Wenxia Lin, Omar Herrera-Asmat, Alexander B Tong, Tiantian Kong, Carlos Bustamante

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wenxia LinDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong 518000, China.
Omar Herrera-AsmatInstitute for Quantitative Biosciences-QB3, University of California, Berkeley, CA 94720, United States.
Alexander B TongInstitute for Quantitative Biosciences-QB3, University of California, Berkeley, CA 94720, United States.
Tiantian KongDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong 518000, China.
Carlos BustamanteInstitute for Quantitative Biosciences-QB3, University of California, Berkeley, CA 94720, United States.ORCID 0000-0002-2970-0073

Funding

THE PHYSICAL CHEMISTRY OF NUCLEIC ACIDSR01GM032543 · NIGMS · UNIVERSITY OF OREGON · PI CARLOS Jose BUSTAMANTE · 1985 to 2026
$6.4M
NIGMS NIH HHS R01 GM032543
6 · The paper itself

Abstract

Single molecule methods have become prevalent tools in elucidating molecular processes across various life science fields over the past three decades, driving breakthroughs in understanding their underlying molecular mechanisms. In our study, we employed two single-molecule methods, Forster Resonance Energy Transfer (smFRET) and high-resolution optical tweezers, to investigate the transcription of

Identifiers

PMID41928957
PMCPMC13041941

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.