Evidence map›Paper›PMID 41928965›Full record

ArticlebioRxiv : the preprint server for biology2026

Adaptive immunity shapes baseline physiology of

Jo Hendrix, Reem Al Mubarak, Karen Rossmassler, Holly Nielsen, Elizabeth Wynn, Camile Moore, Isabelle L Jones, Martin I Voskuil, Brendan K Podell, Gregory T Robertson and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jo HendrixDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9029-2390
Reem Al MubarakDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Karen RossmasslerDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Holly NielsenDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Elizabeth WynnConsortium for Applied Microbial Metrics, Aurora, CO.
Camile MooreConsortium for Applied Microbial Metrics, Aurora, CO.
Isabelle L JonesConsortium for Applied Microbial Metrics, Aurora, CO.
Martin I VoskuilConsortium for Applied Microbial Metrics, Aurora, CO.ORCID 0000-0002-9565-7923
Brendan K PodellConsortium for Applied Microbial Metrics, Aurora, CO.
Gregory T RobertsonConsortium for Applied Microbial Metrics, Aurora, CO.ORCID 0000-0001-7157-4034
Chuangqi WangDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Nicholas D WalterDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-0126-1993

Funding

Preclinical Design and Clinical Translation of TB Regimens (PReDicTR) ConsortiumUM1AI179699 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kelly E. Dooley, ERIC L NUERMBERGER · 2024 to 2026
$22.2M
NIAID NIH HHS UM1 AI179699
6 · The paper itself

Abstract

Preclinical tuberculosis (TB) drug evaluation relies heavily on mouse infection models. Drug efficacy varies depending on inoculum and the timing of treatment initiation. These differences reflect, in part, physiological adaptations of

Identifiers

PMID41928965
PMCPMC13041962

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.