Evidence map›Paper›PMID 41929019›Full record

ArticlebioRxiv : the preprint server for biology2026

Imaging [

Christopher Liang, Titus E Tucker, Ashlee D L Coronel, Ellen H N Nguyen, Janet L Nguyen, Irakli Intskirveli, Ronit Lazar, Raju Metherate, Jogeshwar Mukherjee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.ORCID 0000-0001-9081-294X
Titus E TuckerPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.
Ashlee D L CoronelPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.ORCID 0009-0003-2810-766X
Ellen H N NguyenPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.ORCID 0009-0006-1295-2238
Janet L NguyenPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.
Irakli IntskirveliNeurobiology and Behavior, University of California-Irvine, Irvine, CA 92697.
Ronit LazarNeurobiology and Behavior, University of California-Irvine, Irvine, CA 92697.
Raju MetherateNeurobiology and Behavior, University of California-Irvine, Irvine, CA 92697.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.ORCID 0000-0003-1009-877X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Nicotinic acetylcholinergic receptors (nAChRs), comprising of α and β subunits are present in the brain and whole body. The less abundant α2-subunit is a fast-acting receptor subtype and plays an important role in cognition and learning. To understand cellular functional consequences, this study evaluated glucose metabolism using [ Methods: Control (CN; 4M, 4F), α2 knockout (α2KO; 4M, 4F) and α2 hypersensitive (α2HS; 4M,4F), 12-16 month old mice were used. Mice were fasted and injected with [ Results: The α2HS male mice exhibited the largest brain increase in [ Conclusions: α2 nAChRs plays a significant role in brain activation as exhibited by the increase in [

Indexed as

[18F]FDGBrainInterscapular brown adipose tissueMice modelsnicotinePET/CT

Identifiers

PMID41929019
PMCPMC13041789

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.