Evidence map›Paper›PMID 41929047›Full record

ArticlebioRxiv : the preprint server for biology2026

STAT4-dependent regulation of neuroinflammation in atherosclerosis.

Natalie Stahr, Alina K Moriarty, Shelby D Ma, W Coles Keeter, Woong-Ki Kim, Larry D Sanford, Elena V Galkina

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Natalie StahrDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Alina K MoriartyDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Shelby D MaDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
W Coles KeeterDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Woong-Ki KimDivision of Microbiology, Tulane National Primate Research Center, Department of Microbiology, Covington, LA, USA.
Larry D SanfordDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Elena V GalkinaDepartment of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.ORCID 0000-0002-0001-685X

Funding

Myeloid cell-specific role of STAT4 in atherosclerosis and metabolic dysfunctionR01HL142129 · NHLBI · EASTERN VIRGINIA MEDICAL SCHOOL · PI GALKINA, ELENA V, NADLER, JERRY L. · 2018 to 2021
$2.1M
B cell anergy, modified LDL uptake, and atherosclerosisR01HL139000 · NHLBI · EASTERN VIRGINIA MEDICAL SCHOOL · PI GALKINA, ELENA V · 2018 to 2021
$1.9M
NHLBI NIH HHS R01 HL139000NHLBI NIH HHS R01 HL142129
6 · The paper itself

Abstract

Atherosclerosis is linked to an increased risk of cognitive decline, with chronic inflammation being a common feature of both pathologies. IL-12 activates STAT4 to regulate myeloid cell functions, and blockade of this pathway alleviates cognitive impairment in Alzheimer's models. However, the mechanisms connecting vascular pathology to neuroinflammation remain unclear. Here, we examine whether STAT4 functions as a common mediator of neuroinflammation in atherosclerosis. We demonstrate that LysM

Indexed as

atherosclerosiscognitive functionsimmune responseneuroinflammationSTAT4

Identifiers

PMID41929047
PMCPMC13041899

What Socratic holds

Textmetadata
LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.